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However, any deterioration or damage in this region leads to corneal conjunctivalization and consequent limbal stem cell deficiency (LSCD), which compromises corneal transparency. LSCD is an important condition, especially in the pediatric population, as it can lead to corneal vascularization, opacity and ultimately loss of vision and subsequent amblyopia, unlike adults. Although pediatric LSCD is often due to chemical injuries, as in adults, it is also caused by conditions such as congenital aniridia, Steven Johnson Syndrome and various other immunological disorders. Appropriate and timely treatment in pediatric LSCD is of particular importance in preventing progression to amblyopia, unlike adults. Accurate staging of the disease is essential for the necessary medical and surgical treatment decision. While medical approaches are at the forefront to eliminate the causative agent and improve the ocular surface in reversible cases, it is essential to replace the limbal stem cells lost in advanced disease. For these replacement procedures, it is noteworthy that there is a tendency for minimally invasive methods compared to adults to avoid possible complications due to long life expectancy in children. In conclusion, although there are various reviews on limbal stem cell deficiency (LSCD) in adults, we believe that this review for childhood LSCD will make an important contribution to the literature, since the relevant literature currently reported for the pediatric population is limited.<\/jats:p>","DOI":"10.1177\/11206721241291995","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T09:51:04Z","timestamp":1730281864000},"page":"821-833","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pediatric limbal stem cell deficiency: An overview of a rarely studied pathology"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2394-1888","authenticated-orcid":false,"given":"Nesrin","family":"Tutas G\u00fcnayd\u0131n","sequence":"first","affiliation":[{"name":"Department of Ophtalmology, Istanbul Arel University, Bah\u00e7elievler Memorial Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3333-3349","authenticated-orcid":false,"given":"Ozlem","family":"Barut Selver","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Ege University, Izmir, Turkey"},{"name":"Stem Cell Department, Graduate School of Health Sciences, Ege University, Izmir, Turkey"},{"name":"Limbustem R&amp;D Medical Products Ltd &amp; Ocular Surface Research Laboratory, Ege University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_646_17"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.04.003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/2320-3897.174344"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8086269"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.06.044"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.2308"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002379"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702895"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03905-z"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/480983"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000858"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.01.020"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307179"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.662940"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000116529.35249.fa"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.10.016"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200103000-00005"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.162599"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.05.012"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001820"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.11.003"},{"key":"e_1_3_2_23_2","first-page":"1993","volume-title":"GeneReviews\u00ae [Internet]","author":"Moosajee M","year":"2018","unstructured":"Moosajee M, Hingorani M, Moore AT. 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