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It highlights the role of chronic neuropathic pain in DED and the nociceptive hypothesis, which suggests that psychological stress can exacerbate DED symptoms. Additionally, it explores diagnostic and management strategies for DED, emphasizing the importance of considering psychological aspects to improve patient care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The intricate nature of DED, closely linked to mental health issues, requires a comprehensive diagnostic and therapeutic approach. Addressing neuropathic pain and psychological factors is crucial for effective DED management. Future efforts should focus on developing specific interventions targeting DED's physical and emotional impacts to enhance overall patient well-being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241305661","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T08:59:07Z","timestamp":1734512347000},"page":"1445-1455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Mental burden of ocular surface discomfort"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9051-7928","authenticated-orcid":false,"given":"Antonio","family":"Di Zazzo","sequence":"first","affiliation":[{"name":"Ophthalmology Complex Operative Unit, University Campus Bio-Medico, Rome, Italy"},{"name":"Rare Corneal Diseases Center, Campus Bio-Medico University Hospital Foundation, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"De Gregorio","sequence":"additional","affiliation":[{"name":"Ophthalmology Complex Operative Unit, University Campus Bio-Medico, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Spelta","sequence":"additional","affiliation":[{"name":"Ophthalmology Complex Operative Unit, University Campus Bio-Medico, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senol","family":"Demircan","sequence":"additional","affiliation":[{"name":"Alcon Management Sa, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70082-4"},{"key":"e_1_3_2_3_2","first-page":"746","article-title":"Burning eye syndrome: do neuropathic pain mechanisms underlie chronic dry eye?","volume":"17","author":"Kalangara JP","year":"2016","unstructured":"Kalangara JP, Galor A, Levitt RC, et al. 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