{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:46:44Z","timestamp":1777582004061,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Research to Prevent Blindness Unrestricted Grant","award":["GR004596-1"],"award-info":[{"award-number":["GR004596-1"]}]},{"name":"NIH Center Core Grant","award":["P30EY014801"],"award-info":[{"award-number":["P30EY014801"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To describe a case of guttae recurrence in bilateral corneal grafts in a patient with a known diagnosis of Fuchs endothelial dystrophy, more than three decades following penetrating keratoplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case Report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 79-year-old White woman presented with declining vision, right eye worse than the left. She had previously undergone bilateral penetrating keratoplasty (P.K.) for Fuchs Endothelial Keratoplasty 35- and 34- years ago, of the right and left eye respectively. The slit-lamp biomicroscopy exam revealed corneal edema as well as presence of guttae affecting bilateral grafts. She underwent PK of the right eye. Histopathological analysis of the removed PK graft showed posterior nodular excrescences consistent with guttae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Guttae development in corneal grafts is relatively uncommon and the mechanism of this entity remains unclear. The observation of guttae development in transplanted grafts has raised questions surrounding donor cornea screening and evaluation by eye banks, as well as those relating to recipients\u2019 genetics and intrinsic factors that lead to guttae recurrence in the transplanted grafts. We herein describe the case of guttae recurrence in bilateral corneal grafts in a patient with a known diagnosis of Fuchs endothelial dystrophy, more than 34 years following penetrating keratoplasty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241313000","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:39:56Z","timestamp":1736487596000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Late corneal guttae recurrence in bilateral penetrating keratoplasty grafts"],"prefix":"10.1177","volume":"35","author":[{"given":"Andrea C","family":"Santiago-Leon","sequence":"first","affiliation":[{"name":"Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charissa H","family":"Tan","sequence":"additional","affiliation":[{"name":"Florida Lions Ocular Pathology Laboratory, University of Miami Miller School of Medicine, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander R","family":"Dubovy","sequence":"additional","affiliation":[{"name":"Florida Lions Ocular Pathology Laboratory, University of Miami Miller School of Medicine, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-2775","authenticated-orcid":false,"given":"Ellen H","family":"Koo","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306569"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15195"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000003287"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1401-2"},{"key":"e_1_3_2_6_2","article-title":"32 Corneal guttae after descemet membrane endothelial keratoplasty (DMEK)","volume":"7","author":"Groeneveld-van Beek EA","year":"2022","unstructured":"Groeneveld-van Beek EA, Vasanthananthan K, Lie JT, et al. 32 Corneal guttae after descemet membrane endothelial keratoplasty (DMEK). BMJ Open Ophthalmol 2022; 7: A13\u2013Aa4.","journal-title":"BMJ Open Ophthalmol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002971"},{"key":"e_1_3_2_8_2","first-page":"44","article-title":"Denovo development of corneal guttae and Fuchs\u2019 dystrophy in corneal grafts","volume":"26","author":"Alexandrakis G","year":"2000","unstructured":"Alexandrakis G, Filatov V, Adamis AP. Denovo development of corneal guttae and Fuchs\u2019 dystrophy in corneal grafts. CLAO J 2000; 26: 44\u201346.","journal-title":"CLAO J"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3091695"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0453-x"},{"key":"e_1_3_2_12_2","first-page":"295","article-title":"REVIEW: current understanding of the pathogenesis of Fuchs\u2019 endothelial corneal dystrophy","volume":"25","author":"Nanda GG","year":"2019","unstructured":"Nanda GG, Alone DP. 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