{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:47:01Z","timestamp":1777582021842,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate macular and peripapillary microvascular changes after proton beam radiotherapy for iris melanoma using optical coherence tomography angiography (OCT-A).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients treated with proton beam radiotherapy for iris melanoma were included in the iris melanoma group. Fellow eyes were used as controls. Vessel density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) of the macula, radial peripapillary capillary plexus (RPCP) and foveal avascular zone (FAZ) were evaluated using OCT-A. Central macular thickness (CMT) and nerve fiber layer thickness (RNFL) were also investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 11 patients were included. Vessel density in the whole SCP was comparable between treated eyes and untreated fellow eyes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.32). Vessel density in the whole DCP was lower in the iris melanoma group compared with untreated fellow eyes: 39% [standard deviation (SD) 1.9] versus 49% (SD 4.1), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Vessel density of the whole RPCP was lower in the iris melanoma group compared with untreated fellow eyes: 44% (SD 3.5) versus 48% (SD 2.2), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). No differences between treated eyes and untreated fellow eyes were noted when evaluating FAZ, CMT and RNFL thickness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Irradiation of the iris may determine vascular damage in the uveal tract, which, consequently, can affect the retinal vascular network. Changes in OCT-A parameters detected in DCP and RPCP may be early signs of microvascular impairment in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251319822","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T17:31:46Z","timestamp":1741887106000},"page":"1382-1388","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Microvascular changes after proton beam radiotherapy for iris melanoma: An optical coherence tomography angiography study"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2639-1321","authenticated-orcid":false,"given":"Matteo","family":"Fallico","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresio","family":"Avitabile","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Alosi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0648-1040","authenticated-orcid":false,"given":"Edoardo","family":"Dammino","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Reibaldi","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8881-0926","authenticated-orcid":false,"given":"Paola","family":"Marolo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-618X","authenticated-orcid":false,"given":"Guglielmo","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-6686","authenticated-orcid":false,"given":"Niccol\u00f2","family":"Castellino","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenza","family":"Bonfiglio","sequence":"additional","affiliation":[{"name":"Department of Experimental Biomedicine and Clinical Neuroscience, Ophthalmology Section, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Caltabiano","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia\u2014Section of Anatomic Pathology, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Broggi","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia\u2014Section of Anatomic Pathology, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Foti","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia\u201d, University of Catania -Radiology I Unit, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Spatola","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia\u201d, University of Catania -Radiology I Unit, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ragusa","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences\u2014Section of Biology and Genetics, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Barbagallo","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences\u2014Section of Biology and Genetics, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-5031","authenticated-orcid":false,"given":"Enrico","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy"},{"name":"Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/app11177874"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01145"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/app10248766"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030775"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2021.5190"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.10.009"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.06.053"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.09.033"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2020.08.007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-019-04347-6"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003253"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14315"},{"key":"e_1_3_2_14_2","first-page":"1","article-title":"Microvascular changes after scleral buckling for rhegmatogenous retinal detachment: an optical coherence tomography angiography study","volume":"12","author":"Fallico M","year":"2022","unstructured":"Fallico M, Longo A, Avitabile T, et al. Microvascular changes after scleral buckling for rhegmatogenous retinal detachment: an optical coherence tomography angiography study. Diagnostics (Basel, Switzerland) 2022; 12: 1\u201311. doi:https:\/\/doi.org\/10.3390\/DIAGNOSTICS12123015","journal-title":"Diagnostics (Basel, Switzerland)"},{"key":"e_1_3_2_15_2","article-title":"Optical coherence tomography angiography features in post COVID-19 pneumonia patients: a pilot study","author":"Cennamo G","unstructured":"Cennamo G, Reibaldi M, Montorio D, et al. Optical coherence tomography angiography features in post COVID-19 pneumonia patients: a pilot study. Am J Ophthalmol March 2021. doi:https:\/\/doi.org\/10.1016\/j.ajo.2021.03.015","journal-title":"Am J Ophthalmol"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.10.001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22324"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-01237-8"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001021"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061618"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-0819-y"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000844"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2018.1437922"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000495624"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001085"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11123426"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721251319822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721251319822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721251319822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:47:16Z","timestamp":1777405636000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721251319822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/11206721251319822"],"URL":"https:\/\/doi.org\/10.1177\/11206721251319822","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]}}}