{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:18:06Z","timestamp":1777580286173,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the effect of delayed postoperative mitomycin C (MMC) application on surgical outcome and bleb morphology with intra-operative application in trabeculectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This monocentric, unmasked randomized control trial recruited primary glaucoma patients between 18\u201370 years of age. They were randomized into Group I (intraoperative MMC group) and Group II (postoperative MMC group). All patients underwent standard fornix-based trabeculectomy with differences only in the MMC application step. In Group I, 0.2\u2005mg\/ml MMC was applied intraoperatively for two minutes, while in Group II, 0.01\u2005mg (0.25\u2005ml of 0.04\u2005mg\/ml) of MMC was injected 7\u201314 days postoperatively above the bleb. The primary outcome was surgical success, whereas the secondary outcome measures were rate of complications and bleb morphology. Complete and qualified success was defined as intraocular pressure (IOP) between 6\u201321\u2005mm Hg without and with \u22642 anti-glaucoma medications (AGMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty-six eyes (31 in Group I and 25 in Group II) were analyzed for the outcome at 18 months follow-up. Surgical success was comparable (70.9% vs 68%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.811) between the groups. There were higher incidences of hypotony (41.9% vs 36%) in Group I. Incidences of persistent-hypotony (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032) and late-hypotony (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.127) were higher in Group I. Two eyes developed hypotony maculopathy in Group I, while none in Group II. The blebs in Group I were more avascular, cystic and developed thinning, while those in Group II were diffuse and shallow.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Delayed postoperative MMC application may be as effective as standard trabeculectomy with MMC in lowering IOP with a lower rate of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251327650","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T02:54:38Z","timestamp":1742784878000},"page":"1666-1674","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparing the outcome of delayed postoperative versus intraoperative mitomycin C use in trabeculectomy: A randomized control trial"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4655-9961","authenticated-orcid":false,"given":"Ashok Kumar","family":"Singh","sequence":"first","affiliation":[{"name":"Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1353-8665","authenticated-orcid":false,"given":"Natasha","family":"Gautam","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5068-7435","authenticated-orcid":false,"given":"Faisal","family":"Thattaruthody","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhuri","family":"Akella","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2976-121X","authenticated-orcid":false,"given":"Srishti","family":"Raj","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-5497","authenticated-orcid":false,"given":"Sushmita","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5275-6235","authenticated-orcid":false,"given":"Surinder Singh","family":"Pandav","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1990.54"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(87)90091-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200404000-00015"},{"key":"e_1_3_2_5_2","first-page":"1945","article-title":"A review of the efficacy of mitomycin C in glaucoma filtration surgery","volume":"9","author":"Habash A","unstructured":"Habash A, Aljasim A, Owaidhah LA, et al. A review of the efficacy of mitomycin C in glaucoma filtration surgery. Clin Ophthalmol 2015 Oct 20; 9: 1945\u20131951.","journal-title":"Clin Ophthalmol"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700148"},{"key":"e_1_3_2_7_2","first-page":"101","article-title":"Subconjunctival injection of low-dose mitomycin-C for treatment of failing human trabeculectomies","volume":"20","author":"Apostolov VI","unstructured":"Apostolov VI, Siarov NP. Subconjunctival injection of low-dose mitomycin-C for treatment of failing human trabeculectomies. Int Ophthalmol 1996\u20131997; 20: 101\u2013105.","journal-title":"Int Ophthalmol"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200306000-00015"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.06.018"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00188"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100160139001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002897"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00279-7"},{"key":"e_1_3_2_14_2","first-page":"618","article-title":"Clinical experiences and results of mitomycin C in trabeculectomy","volume":"220","author":"Laube T","year":"2003","unstructured":"Laube T, Ritters B, Selbach M, et al. Clinical experiences and results of mitomycin C in trabeculectomy. Klin Monbl Augenheilkd 2003; 220: 618\u2013624.","journal-title":"Klin Monbl Augenheilkd"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.1996.10.1.42"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-3028-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.6.686"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10008-1159"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0429"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.10.017"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080200029011"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.4.443"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.8.926"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.57"},{"key":"e_1_3_2_25_2","first-page":"389","article-title":"Hypotony maculopathy following the use of topical mitomycin C in glaucoma filtration surgery","volume":"24","author":"Costa VP","unstructured":"Costa VP, Wilson RP, Moster MR, et al. Hypotony maculopathy following the use of topical mitomycin C in glaucoma filtration surgery. Ophthalmic Surg 1993 Jun; 24: 389\u2013394. PMID: 8336889.","journal-title":"Ophthalmic Surg"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01069-2"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2024.01.008"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.10.1341"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000068250"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721251327650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721251327650","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721251327650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:41:05Z","timestamp":1777405265000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721251327650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,23]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/11206721251327650"],"URL":"https:\/\/doi.org\/10.1177\/11206721251327650","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,23]]}}}