{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:10:59Z","timestamp":1788520259209,"version":"build-2803163510"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The glucagon-like peptide-1 receptor agonists (GLP-1 RAs) such as Semaglutide, have revolutionized the treatment of type 2 diabetes mellitus and obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case desciption<\/jats:title>\n                    <jats:p>The aim of the present study was to report a case of Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) occurring in a diabetic patient taking Semaglutide and to review the literature in order to find a possible relation between the ophthalmological event and the drug intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Although the clinical trials of Semaglutide did not report any significant increase in the risk of NAION, a recent retrospective cohort study suggested a possible association between NAION and GLP-1 RAs. After this publication, the association between NAION and Semaglutide became an hot topic and several studies were published, presenting conflicting results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Importance<\/jats:title>\n                    <jats:p>Albeit the association between the use of GLP-1 RAs and NAION, to date, remain controversial, clinicians and ophthalmologists should be aware of such possible association to analyze for each patient the risk-benefit ratio.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251331655","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T07:24:30Z","timestamp":1743751470000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Non arteritic ischemic optic neuropathy in a patient taking semaglutide: Is there a relation? A case report and a review of the literature"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-7486","authenticated-orcid":false,"given":"Martina","family":"Maceroni","sequence":"first","affiliation":[{"name":"Istituto di Oftalmologia, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italia"},{"name":"UOC Oculistica, Fondazione Policlinico Universitario A. Gemelli - IRCCS, 00168 Roma, Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sasso","sequence":"additional","affiliation":[{"name":"UOC Oculistica, Fondazione Policlinico Universitario A. Gemelli - IRCCS, 00168 Roma, Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Giarletti","sequence":"additional","affiliation":[{"name":"UOC Oculistica, Fondazione Policlinico Universitario A. 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