{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:18:15Z","timestamp":1777580295812,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005809","name":"Hyderabad Eye Research Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100005809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the presence of stem cells within the lacrimal drainage system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective interventional case series where human lacrimal sac tissue biopsies were obtained from patients undergoing endoscopic dacryocystorhinostomy or a dacryocystectomy surgery at a tertiary care Dacryology Services. Histopathology, immunohistochemistry, and gene expression studies were performed to check the expression of several basic stem\/progenitor specific genes \u2212\n                      <jats:italic>Cd90, Cd105, Cd73<\/jats:italic>\n                      ,\n                      <jats:italic>Abcb5, Abcg2,<\/jats:italic>\n                      and\n                      <jats:italic>P63\u03b1.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The lacrimal sac showed positive expression of general stem cell markers (ABCB5, ABCG2, and P63\n                      <jats:italic>\u03b1)<\/jats:italic>\n                      and mesenchymal stem cell-specific markers\n                      <jats:italic>(CD73, CD90, CD105)<\/jats:italic>\n                      using transcriptional and immunolocalization studies\n                      <jats:italic>.<\/jats:italic>\n                      Interestingly, CD73 and CD105 double-positive cells and CD73 and CD90 double-positive cells (specific markers for mesenchymal stem cells) were noted in the lacrimal sac stroma and were confirmed not to be vascular endothelial cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study is proof of the principle of the presence of a wide range of stem cell markers within the human lacrimal sac. This study could serve as a foundation for investigating the stem cells and characterizing them further to better understand the lacrimal drainage disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251333826","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T03:16:01Z","timestamp":1745205361000},"page":"1795-1802","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The presence of stem cells in the human lacrimal drainage system: A proof of principle study"],"prefix":"10.1177","volume":"35","author":[{"given":"Tejaswini","family":"Pingali","sequence":"first","affiliation":[{"name":"Center for Ocular Regeneration (CORE), Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India"},{"name":"Manipal Academy of Higher Education (MAHE), Manipal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilip K","family":"Mishra","sequence":"additional","affiliation":[{"name":"Manipal Academy of Higher Education (MAHE), Manipal, India"},{"name":"Ocular Pathology Services, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Singh","sequence":"additional","affiliation":[{"name":"Center for Ocular Regeneration (CORE), Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6363-9202","authenticated-orcid":false,"given":"Mohammad Javed","family":"Ali","sequence":"additional","affiliation":[{"name":"Govindram Seksaria Institute of Dacryology, L. V. 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