{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:18:15Z","timestamp":1777580295848,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the role of external limiting membrane aperture (ELMA) as a prognostic factor for the anatomical and functional outcomes of full thickness macular hole (FTMH) surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>120 eyes of 120 patients who underwent surgery for idiopathic FTMH were enrolled. Best corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT) scans were evaluated preoperatively and postoperatively at 3 and 12 months. Statistical analysis was performed to correlate the following preoperative parameters with 12-months postoperative BCVA and anatomical results: ELMA, apical hole diameter (AD), base hole diameter (BD), macular hole index (MHI), tractional hole index (THI), height (H), diameter hole index (DHI), hole form factor (HFF) and preoperative BCVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Primary successful MH closure was achieved in all the eyes. Postoperative BCVA showed a statistically significant increase from a preoperative logMAR median (IQR) value of 0.70 (0.52\u20131.00) to 0.18 (0.10\u20130.34) at 3 months and 0.16 (0.05\u20130.30) at 12 months. As demonstrated by ROC curves analysis, ELMA revealed to be a good predictor for 1B and 1C types of MH closure when its value was greater than 369\u2005\u00b5m. Moreover, ELMA sizes above 369\u2005\u00b5m were strongly associated with a postoperative BCVA less than 20\/40.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ELMA appears to be a reliable prognostic factor for postoperative anatomical and functional outcome in FTMH surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251334161","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T10:48:32Z","timestamp":1744714112000},"page":"1854-1862","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["External limiting membrane aperture as a reliable and predictive prognostic factor in macular hole surgery"],"prefix":"10.1177","volume":"35","author":[{"given":"Gian Marco","family":"Guerin","sequence":"first","affiliation":[{"name":"Eye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4725-1590","authenticated-orcid":false,"given":"Marco R","family":"Pastore","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-9217","authenticated-orcid":false,"given":"Pier Luigi","family":"Guerin","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Grotto","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2854-4141","authenticated-orcid":false,"given":"Leandro","family":"Inferrera","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Tognetto","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, Trieste, 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