{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:05:37Z","timestamp":1792598737571,"version":"4.5.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the long-term outcomes of next-generation tyrosine kinase inhibitor (TKI) therapy in patients with choroidal metastases (CMs) secondary to non-small cell lung cancer (NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Major Findings<\/jats:title>\n                    <jats:p>This case series includes five eyes from three patients with stage IV NSCLC and CMs. All patients presented with unilateral visual loss, though two exhibited bilateral choroidal lesions on multimodal imaging, including fundus photography, dye-based angiography, optical coherence tomography (OCT), and ultrasonography. Systemic evaluation confirmed ALK-rearranged NSCLC (case 1) and EGFR-mutated NSCLC (cases 2 and 3), leading to first-line treatment with Alectinib and Osimertinib, respectively. Within months of therapy initiation, significant anatomical and visual improvements were noted, with complete lesion resolution and photoreceptor restoration by 6 months. At final follow-up (24\u201336 months), high-resolution OCT showed residual granularity in the outer retinal layers, while OCT angiography (OCTA) revealed persistent choriocapillaris flow voids. Microperimetry demonstrated distinct functional alterations based on lesion location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This series highlights favorable long-term outcomes in NSCLC patients with CMs treated with next-generation TKIs. It underscores the value of multimodal imaging and functional assessments in monitoring disease progression and treatment response, emphasizing the importance of early targeted therapy in optimizing visual outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251337129","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T02:49:50Z","timestamp":1746586190000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Multimodal imaging and functional outcomes of choroidal metastases from non-small cell lung cancer treated with targeted therapy"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7750-1989","authenticated-orcid":false,"given":"Giuliano","family":"Gualandi","sequence":"first","affiliation":[{"name":"Eye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0458-9727","authenticated-orcid":false,"given":"Francesco","family":"Romano","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy"},{"name":"Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lamanna","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy"},{"name":"NIHR Moorfields Biomedical Research Centre and Clinical Research Facility, Moorfields Eye Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8330-295X","authenticated-orcid":false,"given":"Chiara","family":"Preziosa","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Staurenghi","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30148-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1974.01010010286003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.014"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S315532"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.12.024"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx702"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07630-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000448114"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx703"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2306434"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8488-16"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.18502\/jovr.v17i1.10178"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2022.101459"},{"key":"e_1_3_2_16_2","first-page":"2015","article-title":"Spare the rods, save the cones in aging and age-related maculopathy","volume":"41","author":"Curcio CA","year":"2000","unstructured":"Curcio CA, Owsley C, Jackson GR. Spare the rods, save the cones in aging and age-related maculopathy. Invest Ophthalmol Vis Sci 2000; 41: 2015\u20132018.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/IAE.0000000000003951","article-title":"Correlation between microperimetry and imaging in extensive macular atrophy with pseudodrusen-like appearance (EMAP)","volume":"44","author":"Romano F","year":"2024","unstructured":"Romano F, Boon CJF, Invernizzi A, et al. Correlation between microperimetry and imaging in extensive macular atrophy with pseudodrusen-like appearance (EMAP). Retina 2024; 44: 246\u2013254.","journal-title":"Retina"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721251337129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721251337129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721251337129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:41:14Z","timestamp":1777405274000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721251337129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/11206721251337129"],"URL":"https:\/\/doi.org\/10.1177\/11206721251337129","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,6]]}}}