{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:18:17Z","timestamp":1777580297687,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Refractive surgery, including procedures like photorefractive keratectomy (PRK) and laser-assisted in situ keratomileusis (LASIK), is increasingly common and generally safe, offering favorable optical outcomes. However, patients' anamnesis often lacks significant clinical information, such as systemic treatments for acne, diabetes, and polycystic ovary syndrome. Isotretinoin, a systemic treatment for severe acne, is rarely associated with corneal abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient and Clinical Findings<\/jats:title>\n                    <jats:p>This case report presents a 26-year-old female who underwent PRK for her myopic refractive error in both eyes, without disclosing her systemic isotretinoin therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis, Intervention, and Outcomes<\/jats:title>\n                    <jats:p>Post-surgery, she developed fine bilateral basal membrane irregularities and subepithelial interface alterations. Despite a change in topical therapy, subepithelial haze persisted but improved over time, achieving an uncorrected distance visual acuity of 20\/20 in both eyes at 2.5 months from surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Isotretinoin can induce ocular surface changes, including corneal epithelial thickening and stromal thinning, dry eye symptoms, and conjunctival modifications. Concurrent UVB exposure during corneal healing can exacerbate these effects, causing metabolic activation, extracellular matrix production, and corneal thickening. This case report highlights the importance of deepened patient's anamnesis before refractive surgery and suggests further studies on the relative contraindication of perioperative isotretinoin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251337160","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T03:24:22Z","timestamp":1745897062000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Isotretinoin-related post-surgical interface alterations during sun light exposure: A case report"],"prefix":"10.1177","volume":"35","author":[{"given":"Sara","family":"Spelta","sequence":"first","affiliation":[{"name":"Ophthalmology Campus Bio-Medico University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9051-7928","authenticated-orcid":false,"given":"Antonio","family":"Di Zazzo","sequence":"additional","affiliation":[{"name":"Ophthalmology Campus Bio-Medico University, Rome, Italy"},{"name":"Ophthalmology Operative Complex Unit, Campus Bio-Medico University Hospital Foundation, Rome, Italy"},{"name":"Cornea Rare Diseases Center, Campus Bio-Medico University Hospital Foundation, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariateresa","family":"Laborante","sequence":"additional","affiliation":[{"name":"Ophthalmology Campus Bio-Medico University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"De Luca","sequence":"additional","affiliation":[{"name":"Ophthalmology Campus Bio-Medico University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Barone","sequence":"additional","affiliation":[{"name":"Ophthalmology Campus Bio-Medico University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Coassin","sequence":"additional","affiliation":[{"name":"Ophthalmology Campus Bio-Medico University, Rome, Italy"},{"name":"Ophthalmology Operative Complex Unit, Campus Bio-Medico University Hospital Foundation, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200003000-00020"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(85)90676-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d3353"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.060"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.05.009"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000769"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/701361"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2022.2050747"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067210901900204"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.635399"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181a16858"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002229"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033700"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(00)00742-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-023-00782-1"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.574332"},{"key":"e_1_3_3_18_2","article-title":"Central corneal thickness and endothelial cell changes in diabetics and age-matched non-diabetics in a tertiary care hospital in central India","volume":"16","author":"Daigavane S","year":"2024","unstructured":"Daigavane S, Mallareddy V. Central corneal thickness and endothelial cell changes in diabetics and age-matched non-diabetics in a tertiary care hospital in central India. 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