{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:01Z","timestamp":1787019121871,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the efficacy and safety of phacoemulsification combined with endocyclophotocoagulation (ECP) and iStent implantation in surgically na\u00efve patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective observational cross-sectional series of 82 surgically na\u00efve eyes treated with combined phacoemulsification, ECP and iStent between January 2018 and July 2019 at a single centre facility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 82 eyes underwent the procedure. Average age was 80.9 (\u00b16.4) years and 61% were female. Fifteen (18.29%) eyes had preperimetric glaucoma, the remaining were primary open angle glaucoma as follows: mild 32.92% (N\u2009=\u200927), moderate 35.37% (N\u2009=\u200929) and advanced 13.41% (N\u2009=\u200911). Baseline mean IOP was 19.5 (\u00b14.5) mmHg, falling to 14.4 (\u00b13.2) mmHg at 36-months (p\u2009\u2264\u20090.001). 82% of eyes were a qualified success at 3-year post-op with IOP\u2009\u2264\u200918\u2005mmHg. 26% of eyes were a complete success at 3-years with IOP\u2009\u2264\u200918\u2005mmHg and no medications. At baseline, mean number of medications was 2 reducing to 1.3\u2009\u00b1\u20091.1 at 3-years; Nineteen (23.2%) were patients medication-free. Best corrected visual acuity improved, increasing from 0.28\u2009\u00b1\u20090.2 LogMAR preoperatively to 0.10\u2009\u00b1\u20090.1 LogMAR at 36-months follow-up (p\u2009\u2264\u20090.001). Two patients developed cystoid macular oedema that resolved with topical treatment. Average MD remained stable over 3-years (p\u2009=\u20090.94). Due to suboptimal IOP, 3 patients underwent selective laser trabeculoplasty (SLT). No patients required further glaucoma surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combination of cataract surgery with iStent and ECP is a safe and effective procedure to lower IOP and medication burden. The procedure halted glaucoma progression and prevented further surgery over a 3-years follow up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251338996","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:04:26Z","timestamp":1746173066000},"page":"2083-2090","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Three-years follow-up of combined phacoemulsification, iStent and endocyclophotocoagulation"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-8021","authenticated-orcid":false,"given":"Celia","family":"Fernandez-Alcalde","sequence":"first","affiliation":[{"name":"Queen Victoria Hospital NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Jones","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4095-0751","authenticated-orcid":false,"given":"Anca Delia","family":"Pantalon","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospitals NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokulan","family":"Ratnarajan","sequence":"additional","affiliation":[{"name":"Queen Victoria Hospital NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"1901","volume-title":"The pathophysiology and treatment of glaucoma: a review","author":"Weinreb RN","year":"2014","unstructured":"Weinreb RN, Aung T, Medeiros FA. 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