{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:18:30Z","timestamp":1777580310064,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To present a case of non-uveal intraocular metastatic disease originating from relapsed breast carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a 67-year-old female with a history of HER2-positive breast carcinoma in remission and recent squamous cell carcinoma of the esophagus presenting with ocular symptoms. Comprehensive ophthalmic examinations and multimodal imaging were performed. Diagnostic procedures included diagnostic vitrectomy and cytology analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient was found to have metastatic carcinoma to the vitreous and retina with an immunophenotype compatible with breast carcinoma. Neurological symptoms led to the discovery of metastatic brain lesions. The patient underwent palliative systemic treatment and stereotactic brain irradiation. Follow-up showed the progression of the ocular lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case informs on the clinical and pathological findings of a rare non-uveal intraocular metastatic disease originating from relapsed breast carcinoma. Vitreous biopsy and multimodal imaging were required for a proper diagnosis and management and would serve as a reference for further cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251340582","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T03:12:33Z","timestamp":1746673953000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathologic correlations and multimodal imaging of vitreoretinal metastasis from breast carcinoma"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-9976","authenticated-orcid":false,"given":"Andrea","family":"Montesel","sequence":"first","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust, London, UK"},{"name":"Fondation Asile des Aveugles, Jules Gonin Eye Hospital, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2113-1790","authenticated-orcid":false,"given":"Basil","family":"Suresh","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Thaung","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust, London, UK"},{"name":"Institute of Ophthalmology, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-4353","authenticated-orcid":false,"given":"Siegfried K.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1561-3059","authenticated-orcid":false,"given":"Hung-Da","family":"Chou","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Arora","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Rees","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30148-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.2406"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0469-1"},{"key":"e_1_3_2_5_2","first-page":"100064","article-title":"Lung adenocarcinoma with metastasis to the vitreous \u2013 A case report and review of literature","volume":"3","author":"Singh M","year":"2021","unstructured":"Singh M, Thomas VM, Lia NL, et al. Lung adenocarcinoma with metastasis to the vitreous \u2013 A case report and review of literature. Curr Probl Cancer: Case Rep 2021; 3: 100064.","journal-title":"Curr Probl Cancer: Case Rep"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/09273940903144705"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3429-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2024.102035"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000506949"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","DOI":"10.1097\/00006982-198200230-00010","article-title":"Diagnostic vitrectomy in metastatic breast carcinoma in the vitreous","volume":"2","author":"Piro P","year":"1982","unstructured":"Piro P, Pappas HR, Erozan YS, et al. Diagnostic vitrectomy in metastatic breast carcinoma in the vitreous. RETINA 1982; 2: 182\u2013183.","journal-title":"RETINA"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200404000-00006"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070120096036"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2006.01148.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/783163"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.09.018"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)94011-8"},{"key":"e_1_3_2_17_2","article-title":"Infiltrative optic neuropathy in advanced breast carcinoma","volume":"15","author":"Shahrudin NFH","year":"2023","unstructured":"Shahrudin NFH, Muhammed J, Wan Hitam WH. Infiltrative optic neuropathy in advanced breast carcinoma. Cureus 2023; 15: e50994.","journal-title":"Cureus"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721251340582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721251340582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721251340582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:41:21Z","timestamp":1777405281000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721251340582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/11206721251340582"],"URL":"https:\/\/doi.org\/10.1177\/11206721251340582","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]}}}