{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:09:00Z","timestamp":1784020140803,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Retinitis pigmentosa masquerades are a rare condition, often associated with paraneoplastic autoimmune retinopathy, specifically in patients with aggressive treatments. This case reports a patient with lung cancer in remission who developed progressive vision loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A 55-year-old male with a history of squamous cell carcinoma of the lung in remission for one year, presented with photophobia and progressive vision loss over 6 months. Visual acuity was 0.2 in the right eye and 0.5 in the left. Fundus examination revealed peripheral pigmented specks, and OCT showed preservation of the subfoveal ellipsoid zone. Anti-enolase antibodies were positive. ERG showed abolished rod responses, absent photopic responses, and diffuse peripheral alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management<\/jats:title>\n                    <jats:p>Given the positive anti-enolase antibodies and clinical presentation, the patient was treated with corticosteroids, immunoglobulins, and Rituximab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome<\/jats:title>\n                    <jats:p>The patient showed visual acuity improvement (BCVA 0.3 OD and 0.9 OS) and stabilization of visual field deficits. New PEV testing showed mild changes in amplitudes and delayed latency in the right eye.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the association between lung cancer and autoimmune retinopathy, likely contributing to the appearance of retinosis pigmentaria masquerades. Early diagnosis and treatment with immunosuppressive therapy can lead to functional recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251345516","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T19:01:22Z","timestamp":1747854082000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Paraneoplastic autoimmune retinopathy associated with anti-enolase antibodies in a patient with lung cancer remission"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-1446","authenticated-orcid":false,"given":"Francisco","family":"Calleja Casado","sequence":"first","affiliation":[{"name":"Ophthalmology Service \u2013 Hospital Cl\u00ednico Universitario de Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Garc\u00eda Ibor","sequence":"additional","affiliation":[{"name":"Ophthalmology Service \u2013 Hospital Cl\u00ednico Universitario de Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-7367","authenticated-orcid":false,"given":"Noem\u00ed","family":"Ruiz del Rio","sequence":"additional","affiliation":[{"name":"Ophthalmology Service \u2013 Hospital Cl\u00ednico Universitario de Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Duch Samper","sequence":"additional","affiliation":[{"name":"Ophthalmology Service \u2013 Hospital Cl\u00ednico Universitario de Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"761","volume-title":"Medical retina","author":"Gregory-Evans K","unstructured":"Gregory-Evans K, Pennesi ME, Weleber RG. Retinitis Pigmentosa and allied disorders [Internet]. In: Medical retina. Elsevier Inc., 2012 [cited 2025 Feb 5], pp.761\u2013835. Available from: http:\/\/www.scopus.com\/inward\/record.url?scp=84906804434&partnerID=8YFLogxK."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175620"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.03.005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-202236"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.09.019"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000531624"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2004.06.003"},{"key":"e_1_3_2_9_2","first-page":"3478","article-title":"Anti\u2013enolase antibodies block enolase function and induce apoptosis of retinal cells","volume":"46","author":"Adamus G","year":"2005","unstructured":"Adamus G, Magrys A, Ren G. Anti\u2013enolase antibodies block enolase function and induce apoptosis of retinal cells. 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