{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:08:56Z","timestamp":1784020136293,"version":"3.55.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the alterations in various ocular parameters in patients undergoing hemodialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 113 eyes from 113 patients who underwent hemodialysis due to chronic kidney disease and acute kidney injury between January 2021 and August 2022. All participants underwent complete ophthalmic exam which included best corrected visual acuity (BCVA), slit lamp examination, intraocular pressure (IOP) measurement and dilated examination using slit lamp biomicroscope and indirect ophthalmoscope. Optical coherence tomography (OCT) was done for all patients before they underwent hemodialysis and central subfield thickness (CST), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness were assessed. The ophthalmic exam and OCT scan were repeated within 1\u20132\u2005h of hemodialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age (+\/- SD) of the study population was 42.14\u2009\u00b1\u200913.25 years, with 65.5% males. Most participants were aged 41\u201360 years. BCVA and IOP did not change significantly after hemodialysis (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.74 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.37, respectively). Retinal parameters showed significant changes, with decreased CST (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and GCC thickness (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.04). There was no significant change in RNFL thickness (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.44). CST positively correlated with dialysate flow rate and negatively with blood flow rate. A weak correlation was found between GCC thickness and ultrafiltration and dialysate flow rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hemodialysis causes alterations in retinal parameters with a decrease in the CST and GCC thickness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251349681","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T09:56:34Z","timestamp":1750240594000},"page":"2235-2243","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in various ocular parameters of patients undergoing hemodialysis"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-5597","authenticated-orcid":false,"given":"Aseem","family":"Kumar","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6944-1080","authenticated-orcid":false,"given":"Vijaya","family":"Sahu","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somen","family":"Misra","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Rathore","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0848-5172","authenticated-orcid":false,"given":"Bharat","family":"Gurnani","sequence":"additional","affiliation":[{"name":"Department of Cataract, Cornea, External Diseases, Trauma, Ocular Surface, Refractive Surgery and Contact Lenses, Gomabai Netralaya and Research Centre, Neemuch, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0951-7415","authenticated-orcid":false,"given":"Kirandeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Cataract, Paediatric Ophthalmology, Strabismus and Neuro-Ophthalmology, Gomabai Netralaya and Research Centre, Neemuch, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/709862"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.07.029"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.26.4.303.15425"},{"key":"e_1_3_2_5_2","first-page":"109","article-title":"Effect of hemodialysis on visual acuity, intraocular pressure, and macular thickness in patients with chronic kidney disease","volume":"9","author":"Chelala E","year":"2015","unstructured":"Chelala E, Dirani A, Fadlallah A, et al. Effect of hemodialysis on visual acuity, intraocular pressure, and macular thickness in patients with chronic kidney disease. Clin Ophthalmol 2015; 9: 109\u2013114.","journal-title":"Clin Ophthalmol"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331321"},{"key":"e_1_3_2_7_2","first-page":"66","article-title":"Measurement of foveal thickness by optical coherence tomography in adult haemodialysis patients with diabetic nephropathy","volume":"31","author":"Auyanet I","year":"2011","unstructured":"Auyanet I, Rodr\u00edguez LJ, Bosch E, et al. Measurement of foveal thickness by optical coherence tomography in adult haemodialysis patients with diabetic nephropathy. 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