{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:11:59Z","timestamp":1787019119792,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Retinopathy of prematurity (ROP) is a blinding disease, however largely preventable by timely detection of severe ROP and treatment when required. Clinical use of the DIGIROP decision support tool (DIGIROP-screen and DIGIROP-birth) can help detecting neonates at high risk of sight-threatening severe ROP needing treatment and to reduce unnecessary screening exams in low-risk infants. External validation is necessary before the tool can be used in clinical decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort analysis of all preterm infants who were screened for ROP at the University Hospitals Ghent Belgium from January 1, 2020, to December 31, 2022. Validation of the DIGIROP decision support tools was the primary outcome variable. In a secondary analysis pre-, peri-, and postnatal characteristics were compared in different cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>311 infants were eligible for routine ROP-screening. Infants with a (gestational age) GA beyond 30 weeks (N\u2009=\u200980) and those who died (N\u2009=\u200919) were excluded resulting in 212 infants eligible entered in DIGIROP-birth. 112 infants did not need to be screened according to DIGIROP-birth. This resulted in 94 infants entered in DIGIROP-screen. These infants had a median GA of 27 weeks, a median birth weight (BW) of 892.5\u2005g, and 62.5% were boys. DIGIROP birth showed a sensitivity of 100%. Most important risk factors for ROP across all subgroups are GA, BW.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The DIGIROP decision support tool demonstrated very high performance in our setting. However, multicenter prospective validation studies with large cohorts should confirm our findings before the use of the model can be generalized in Western NICU's with similar levels of care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251362054","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T06:58:36Z","timestamp":1753340316000},"page":"89-96","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Validation of the DIGIROP algorithm in identifying preterm infants at risk for developing retinopathy of prematurity in a Belgian NICU"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-0115","authenticated-orcid":false,"given":"Sophie","family":"Vanhaesebrouck","sequence":"first","affiliation":[{"name":"University Hospitals Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Zecic","sequence":"additional","affiliation":[{"name":"University Hospitals Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linde","family":"Goossens","sequence":"additional","affiliation":[{"name":"University Hospitals Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Keymeulen","sequence":"additional","affiliation":[{"name":"University Hospitals Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Garabedian","sequence":"additional","affiliation":[{"name":"University Hospitals Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"De Meulemeester","sequence":"additional","affiliation":[{"name":"University Hospitals Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Naessens","sequence":"additional","affiliation":[{"name":"University Hospitals Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"De Coen","sequence":"additional","affiliation":[{"name":"University Hospitals Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koenraad","family":"Smets","sequence":"additional","affiliation":[{"name":"University Hospitals Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-023-02921-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2024.102967"},{"key":"e_1_3_2_4_2","article-title":"A review on the incidence and related risk factors of retinopathy of prematurity across various countries","volume":"14","author":"Nair A","year":"2022","unstructured":"Nair A, El Ballushi R, Anklesaria BZ, et al. A review on the incidence and related risk factors of retinopathy of prematurity across various countries. Cureus 2022; 14: e32007. 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Arret\u00e9 royal relatif \u00e0 l\u2019\u00e9valuation qualitative de l\u2019activit\u00e9 m\u00e9dicale dans les h\u00f4pitaux. 1999: 9552\u20139554."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S401122"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2022.10.010"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-053924"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.16504"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2023.105844"},{"key":"e_1_3_2_22_2","first-page":"1075","article-title":"Modifiable risk factors and preventive strategies for severe retinopathy of prematurity","volume":"13","author":"Prasad M","year":"2023","unstructured":"Prasad M, Ingolfsland EC, Christiansen SP. Modifiable risk factors and preventive strategies for severe retinopathy of prematurity. Life (Basel) 2023; 13: 1075. 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