{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:03:26Z","timestamp":1789052606896,"version":"build-2803163510"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare and evaluate the diagnostic performance of OCT-angiography (OCT-A) parameters in diabetic retinopathy (DR) detection compared to fluorescein angiography (FA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross-sectional, prospective study including 118 diabetic patients (214 eyes). All patients had a complete clinical examination with FA as well as macular OCT-A imaging (3\u2009\u00d7\u20093 mm, 6\u2009\u00d7\u20096 mm). We compared the detection of fundamental DR lesions using both imaging modalities and assessed the diagnostic value of different OCT-A parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Microaneurysms were more frequently detected by FA than with OCT-A. Intraretinal microvascular anomalies were equally visualized by OCT-A (0.27\u2009\u00b1\u20090.777) and FA (0.27\u2009\u00b1\u20090.71). Average of foveal avascular zone (FAZ) surface was less significant at superficial capillary plexus (SCP) (0.353\u2009\u00b1\u20090.107\u2005mm\u00b2) compared to deep capillary plexus (DCP) (0.537\u2009\u00b1\u20090,135\u2005mm\u00b2), (p\u2009&lt;\u20090.001). FAZ remodeling was observed even in DR free eyes and was better identified in DCP (61.1%) than SCP (47.2%). Loss of FAZ circularity was estimated at 0.792\u2009\u00b1\u20090.081 and 0.741\u2009\u00b1\u20090.107 respectively in SCP and DCP, (p\u2009&lt;\u20090.001). Average surface area of capillary non-perfusion zones (CNPZ) was 0.487\u2009\u00b1\u20090.514\u2005mm\u00b2 in SCP and 0.145\u2009\u00b1\u20090.223\u2005mm\u00b2 in DCP, (p\u2009&lt;\u20090.001). The Most reliable OCT-A quantitative parameters for DR screening were: CNPZ surface in DCP (p\u2009=\u20090.0046), total vascular density (VDt) in the DCP (p\u2009=\u20090.003) and CNPZ surface in the SCP (p\u2009=\u20090.0027).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OCT-A enables diabetic microvascular abnormalities detection even at a preclinical stage. Certain OCT-A parameters may provide a valuable quantitative approach for diagnosis and grading of DR severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251367571","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T07:25:17Z","timestamp":1754983517000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative analysis of OCT-angiography and fluorescein angiography in imaging diabetic retinopathy: Unveiling new diagnostic insights"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4207-8327","authenticated-orcid":false,"given":"Khallouli","family":"Asma","sequence":"first","affiliation":[{"name":"Principal Military Hospital of Instruction of Tunis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0555-8793","authenticated-orcid":false,"given":"Oueslati","family":"Yassin","sequence":"additional","affiliation":[{"name":"Principal Military Hospital of Instruction of Tunis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4633-1633","authenticated-orcid":false,"given":"Lagneb","family":"Cyrine","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Ibn El Jazzar of Sousse, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-1976","authenticated-orcid":false,"given":"Choura","family":"Racem","sequence":"additional","affiliation":[{"name":"Principal Military Hospital of Instruction of Tunis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6926-4712","authenticated-orcid":false,"given":"Bouchoucha","family":"Saker","sequence":"additional","affiliation":[{"name":"Principal Military Hospital of Instruction of Tunis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-7450","authenticated-orcid":false,"given":"Maalej","family":"Afef","sequence":"additional","affiliation":[{"name":"Principal Military Hospital of Instruction of Tunis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62124-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-015-0026-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.131"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.8.902"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00475-5"},{"key":"e_1_3_2_7_2","first-page":"431","article-title":"The diagnosis of diabetic retinopathy","volume":"20","author":"Lecleire-Collet A","unstructured":"Lecleire-Collet A, Erginay A, Massin P. The diagnosis of diabetic retinopathy. Sang Thrombose Vaisseaux 1 Oct 2008; 20: 431\u2013434.","journal-title":"Sang Thrombose Vaisseaux"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000882"},{"key":"e_1_3_2_9_2","unstructured":"Frequency of adverse systemic reactions after fluorescein angiography: Results of a prospective study. PubMed [Internet]. Disponible sur: https:\/\/pubmed.ncbi.nlm.nih.gov\/1891225\/"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2019.02.010"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1120672119899901"},{"key":"e_1_3_2_12_2","article-title":"Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review","volume":"44","author":"Ds T","unstructured":"Ds T, Gc C, Ty W. Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review. 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