{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:19:01Z","timestamp":1777580341861,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Conjunctival involvement in sarcoidosis typically presents as non-scarring granulomatous inflammation; however, cicatricial conjunctivitis represents a rare and poorly characterised manifestation. There are currently no published reports of sarcoid-related conjunctival granulomas with cicatrising features responding to anti-TNF therapy. We present the first case of biopsy-confirmed conjunctival sarcoidosis with progressive scarring successfully treated with adalimumab after failure of conventional immunosuppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Description<\/jats:title>\n                    <jats:p>A 47-year-old male with biopsy-proven systemic sarcoidosis presented with recurrent anterior uveitis and progressive conjunctival granulomas, unresponsive to corticosteroids and mycophenolate. He developed forniceal foreshortening, symblepharon formation, and a dense cataract. Conjunctival biopsy confirmed non-necrotizing granulomatous inflammation. Adalimumab was initiated following disease progression on conventional therapy. Within six months, ocular surface inflammation resolved, enabling successful cataract surgery and visual rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To our knowledge, this is the first documented case of sarcoid-related cicatricial conjunctivitis with histological confirmation responding favourably to anti-TNF therapy. This report suggests adalimumab may be a valuable option in cases of treatment-resistant ocular surface sarcoidosis and may guide future therapeutic decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251372393","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T15:49:17Z","timestamp":1756136957000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sarcoid conjunctival granuloma responding to biological therapy"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8716-0845","authenticated-orcid":false,"given":"Talha","family":"Soorma","sequence":"first","affiliation":[{"name":"Manchester Royal Eye Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciane Dreher","family":"Irion","sequence":"additional","affiliation":[{"name":"Manchester Royal Eye Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9196-6219","authenticated-orcid":false,"given":"Andrew James","family":"Walkden","sequence":"additional","affiliation":[{"name":"Manchester Royal Eye Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira","family":"Stylianides","sequence":"additional","affiliation":[{"name":"Manchester Royal Eye Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2015.08.009"},{"key":"e_1_3_3_3_2","first-page":"452","article-title":"Intraocular manifestations of systemic sarcoidosis","volume":"36","author":"Ohara K","year":"1992","unstructured":"Ohara K, Okubo A, Sasaki H, et al. Intraocular manifestations of systemic sarcoidosis. Jpn J Ophthalmol 1992; 36: 452\u2013457.","journal-title":"Jpn J Ophthalmol"},{"key":"e_1_3_3_4_2","first-page":"372","article-title":"Conjunctival sarcoidosis: a case series","volume":"18","author":"Manrique Lipa RK","year":"2010","unstructured":"Manrique Lipa RK, Papadaki TG, Kymionis GD, et al. Conjunctival sarcoidosis: a case series. Ocul Immunol Inflamm 2010; 18: 372\u2013376.","journal-title":"Ocul Immunol Inflamm"},{"key":"e_1_3_3_5_2","first-page":"345","article-title":"Sarcoidosis presenting with cicatrizing conjunctivitis","volume":"23","author":"O'Donnell JJ","year":"2015","unstructured":"O'Donnell JJJr, Karakus S, Doroslovacki P, et al. Sarcoidosis presenting with cicatrizing conjunctivitis. 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Mod Rheumatol 2022; 32: 763\u2013772.","journal-title":"Mod Rheumatol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509852"},{"key":"e_1_3_3_9_2","first-page":"953","article-title":"Long-term safety and efficacy of adalimumab in non-infectious uveitis","volume":"102","author":"Suhler EB","year":"2018","unstructured":"Suhler EB, Smith JR, Giles TR, et al. Long-term safety and efficacy of adalimumab in non-infectious uveitis. Br J Ophthalmol 2018; 102: 953\u2013957.","journal-title":"Br J Ophthalmol"},{"key":"e_1_3_3_10_2","first-page":"641","article-title":"Conjunctival biopsy in the diagnosis of systemic sarcoidosis","volume":"15","author":"Dios E","year":"2001","unstructured":"Dios E, Saornil MA, Herreras JM, et al. Conjunctival biopsy in the diagnosis of systemic sarcoidosis. Eye (Lond) 2001; 15: 641\u2013644.","journal-title":"Eye (Lond)"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.9.1333"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721251372393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721251372393","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721251372393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:41:35Z","timestamp":1777405295000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721251372393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/11206721251372393"],"URL":"https:\/\/doi.org\/10.1177\/11206721251372393","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,25]]}}}