{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:08:57Z","timestamp":1784020137458,"version":"3.55.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the differences in punctal dimensions, tear meniscus height (TMH), and cornea epithelium among medically controlled glaucoma patients using anterior segment optical coherence tomography (AS-OCT) and evaluate the parameters that affect the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional, observational study included 80 subjects with primary open-angle glaucoma and 80 normal subjects without glaucoma and ocular symptoms. AS-OCT was used to measure TMH, outer punctal diameter (OPD), punctal depth (PD), and central corneal epithelial thickness (CCET). Correlations for the effect of topical anti-glaucoma medications on OPD, PD, TMH, and CCET were analyzed. The impact of prostaglandin analogs (PGAs) and Beta-blockers on the parameters were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences were found in age and sex between the groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.333 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.635, respectively). Glaucoma patients exhibited significantly narrower OPD (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), TMH (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and CCET (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006). Subjects on longer-duration therapy showed a statistically significant reduction in TMH and CCET (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.022). While the PD value was significantly lower in those using anti-glaucoma medications containing Beta-blockers (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002), the TMH value was significantly lower in those containing PGAs (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009\n                      <jats:italic toggle=\"yes\">0.037<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Topical anti-glaucoma medications affect the OPD, TMH, and CCET in glaucoma patients compared with normal subjects. Topical anti-glaucoma medications usage duration has negative effects on TMH and CCET. Beta-blockers are more effective on the punctum, while PGAs are more effective on the TMH. These findings highlight the utility of AS-OCT in assessing asymptomatic glaucoma patients and its effects on the ocular surface.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251374170","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:17:29Z","timestamp":1756991849000},"page":"2153-2162","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of tear meniscus, punctum, and cornea epithelium using an anterior segment optical coherence tomography in glaucoma"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8557-4673","authenticated-orcid":false,"given":"Neslihan","family":"Sevimli","sequence":"first","affiliation":[{"name":"Fatih Sultan Mehmet Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6791-2915","authenticated-orcid":false,"given":"Banu","family":"A\u00e7\u0131kal\u0131n","sequence":"additional","affiliation":[{"name":"Fatih Sultan Mehmet Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3551-6057","authenticated-orcid":false,"given":"Cansu Selen","family":"\u00c7\u0131plakk\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Fatih Sultan Mehmet Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0732-1041","authenticated-orcid":false,"given":"G\u00fclden","family":"\u00c7a\u011flar","sequence":"additional","affiliation":[{"name":"Fatih Sultan Mehmet Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8965-3726","authenticated-orcid":false,"given":"Abdulkadir","family":"K\u00fc\u00e7\u00fck","sequence":"additional","affiliation":[{"name":"Fatih Sultan Mehmet Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-1534","authenticated-orcid":false,"given":"Cihan","family":"Kerekli","sequence":"additional","affiliation":[{"name":"Fatih Sultan Mehmet Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-022-02322-w"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5935\/0004-2749.2021-0525"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2022.2094714"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S229815"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867326666190725160621"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_618_23"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.4.418"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_2653_22"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181c325b2"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1120672120901698"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181706829"},{"key":"e_1_3_2_13_2","first-page":"172","article-title":"Changing from preserved to preservative-free cyclosporine 0.1% enhanced triple glaucoma therapy: impact on ocular surface disease-a randomized controlled trial","volume":"24","author":"Konstas A-G","year":"2023","unstructured":"Konstas A-G, Boboridis KG, Athanasopoulos GP, et al. 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