{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:40:41Z","timestamp":1782366041048,"version":"3.54.5"},"reference-count":50,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The aim of this systematic review and meta-analysis was to assess the clinical, humanistic, and economic evidence of the OMNI\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Surgical System (OMNI), Visco360 and Trab360 for open-angle glaucoma (OAG).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Search strategies were applied across MEDLINE\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , Web of Science\u2122, Cochrane (January 2016\u2013April 2024) on 16th April 2024. Congress proceedings (2021\u20132024) were searched in July 2024. Studies containing \u226515 patients that reported clinical, humanistic or economic outcomes associated with the use of OMNI, Visco360 or Trab360 for the treatment of adults with OAG were included. Structured summaries were used to summarize findings and a meta-analysis synthesized the data. Risk of bias was assessed using the Newcastle-Ottawa and CHEERS checklists. The protocol was registered on PROSPERO (CRD42024536680).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 29 included publications, 27 reported clinical and 2 reported economic outcomes. OMNI significantly reduced intraocular pressure (IOP) with mean IOP &lt;18 mmHg (11.5\u201317.2 mmHg) at 12 months when used standalone or combined with cataract surgery. The meta-analysis confirmed statistically significant, comparable IOP reductions at months 6, 12 and 24. IOP-lowering medication use decreased from 0.9\u20133.4 at baseline to 0.1\u20132.2 at month 12 (standalone and combination)\n                      <jats:bold>;<\/jats:bold>\n                      these continued months 24\u201336. Adverse events were generally mild and transient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OMNI consistently reduced IOP and medication use demonstrating sustained effects over 24\u00ad\u201336 months with a favorable safety profile, thus supporting its use in patients with OAG. Limitations of this review include the absence of randomized controlled trials. Six studies were assessed as good quality, the remainder showed risk of bias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251376889","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T17:37:31Z","timestamp":1757957851000},"page":"282-295","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Systematic review and meta-analysis of the clinical effectiveness, safety, humanistic and economic burden of the OMNI\n                    <sup>\u00ae<\/sup>\n                    surgical system and its predecessors"],"prefix":"10.1177","volume":"36","author":[{"given":"Obeda","family":"Kailani","sequence":"first","affiliation":[{"name":"King's Ophthalmology Research Unit (KORU), King's College Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh","family":"Mosaed","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz H","family":"Hengerer","sequence":"additional","affiliation":[{"name":"B\u00fcrgerhospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana","family":"Patel","sequence":"additional","affiliation":[{"name":"Bioscript Data Insights (BDI), Bioscript Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna W","family":"\u015awider","sequence":"additional","affiliation":[{"name":"Valid Insight"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Ghinelli","sequence":"additional","affiliation":[{"name":"Valid Insight"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3785-3087","authenticated-orcid":false,"given":"Laura","family":"Wells","sequence":"additional","affiliation":[{"name":"Valid Insight"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Buchholz","sequence":"additional","affiliation":[{"name":"Valid Insight"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Glaucoma","author":"Dietze J","year":"2024","unstructured":"Dietze J, Blair K, Zeppieri M, et al. Glaucoma. Updated 16 March 2024. Florida, US: StatPearls Publishing, 2024."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.06.019"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2021-egsguidelines"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874364100903020059"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92971-w"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.12.1754"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6138132"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta23310"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0000000000000479"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000001077"},{"key":"e_1_3_3_15_2","unstructured":"Sight Sciences. Sight Sciences Launches the Ergo-Series of the OMNI\u00ae Surgical System https:\/\/www.sightsciences.com\/ous\/sight-sciences-introduces-the-next-generation-omni-surgical-system-for-microinvasive-glaucoma-surgery\/ (accessed 13 September 2024). 2023."},{"key":"e_1_3_3_16_2","unstructured":"Food and Drug Administration. Section 510(k). FDA Summary of Safety and Effectiveness of OMNI Surgical System. K173332 https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf17\/K173332.pdf (accessed 10 June 2025). 2017."},{"key":"e_1_3_3_17_2","unstructured":"Food and Drug Administration (FDA). Section 510(k). FDA Summary of Safety and Effectiveness of OMNI Surgical System. K202678 https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf20\/K202678.pdf (accessed 10 June 2025). 2021."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogla.2020.10.001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2147\/opth.S441834"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/1120672121998234"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2147\/opth.S384105"},{"key":"e_1_3_3_22_2","unstructured":"Wells G Shea B O'Connell D et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp (accessed 23 September 2024). 2000."},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-019-1172-8"},{"key":"e_1_3_3_24_2","unstructured":"ISPOR. Consolidated Health Economic Evaluation Reporting Standards (CHEERS 2022) Statement: Updated Reporting Guidance for Health Economic Evaluations. https:\/\/www.equator-network.org\/reporting-guidelines\/cheers\/ (accessed 23 September 2024). 2022."},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/opth.S367896"},{"key":"e_1_3_3_26_2","unstructured":"Flowers B Olander K Dickerson J. Stand-alone canaloplasty and trabeculotomy in psuedophakic eyes with primary open-angle glaucoma: prospective multicenter 24-month outcomes. In: American Glaucoma Society annual meeting Huntington Beach California USA 2024. Abstract."},{"key":"e_1_3_3_27_2","unstructured":"Gallardo M. Ab-Interno Canaloplasty and Trabeculotomy in Pseudophakic Eyes with Mild-Moderate Open Angle Glaucoma: Prospective Multicenter Trial (ORION). 2021. 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