{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:07:14Z","timestamp":1789589234735,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the effect of anti-VEGF intravitreal injection (IVI) on vascularity and size of retinal angiomas using quantitative analysis of color fundus images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Color fundus images of retinal angiomas underwent RGB analysis with ImageJ software. White intensity (mean RGB values) and red ratio (red value\/sum of green and blue values) were calibrated to obtain the white intensity and red indices, respectively. The lesion-disc area ratio was assessed for size changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventeen image sets of 10 angiomatous lesions were analyzed: 6 retinal hemangiomas from 4 eyes (4 patients) with Von Hippel\u2013Lindau disease (VHL) and 4 retinal vasoproliferative tumors (VPT) from 4 eyes (4 patients). Overall, the white intensity index increased from 1.34 to 1.5 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001), and the red index decreased from 1.14 to 0.85 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) post-IVI. In the VHL group, white intensity increased from 1.41 to 1.58 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.013), and the red index decreased from 1.04 to 0.84 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the VPT group, white intensity increased from 1.17 to 1.36 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.031) and red index decreased from 1.39 to 0.87 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.156) after IVI. Lesion-disc area ratio decreased significantly in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti-VEGF induces whitening and reduces the red component of angiomas, diminishing vascularity and facilitating subsequent invasive treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251378581","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T18:34:42Z","timestamp":1758306882000},"page":"312-320","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative analysis of the anti-VEGF effect for retinal capillary hemangiomas and vasoproliferative tumors"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3729-9806","authenticated-orcid":false,"given":"Hwa-Shin","family":"Fang","sequence":"first","affiliation":[{"name":"Shin-Kong Wu Ho-Su Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-420X","authenticated-orcid":false,"given":"Chung-May","family":"Yang","sequence":"additional","affiliation":[{"name":"National Taiwan University"},{"name":"Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Ting","family":"Chang","sequence":"additional","affiliation":[{"name":"Shin-Kong Wu Ho-Su Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4658-1088","authenticated-orcid":false,"given":"Chyi-Huey","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Medicine, Taipei Medical University"},{"name":"School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4657-9113","authenticated-orcid":false,"given":"Cheng-Kuo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shin-Kong Wu Ho-Su Memorial Hospital"},{"name":"National Taiwan University"},{"name":"School of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(01)00245-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00758-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.04.033"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamaophthalmol.524"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjo.2016.04.003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.09.002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.03.016"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2021.1897851"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/11206721221149075"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008213320642"},{"key":"e_1_3_3_12_2","article-title":"Ocular manifestations of von Hippel-Lindau disease","volume":"11","author":"Ruppert MD","year":"2019","unstructured":"Ruppert MD, Gavin M, Mitchell KT, et al. 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