{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:19:24Z","timestamp":1777580364124,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare intraocular pressure (IOP) and retinal nerve fibre layer (RNFL) thickness in patients receiving intravitreal anti-vascular endothelial growth factor (VEGF) injections with and without anterior chamber paracentesis (ACP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre retrospective cohort study included 269 injection-na\u00efve eyes from 210 patients with neovascular age-related macular degeneration (AMD) or diabetic macular oedema (DME). A matched subset of 140 eyes (70 with ACP, 70 without) was selected based on age, sex, diagnosis, laterality, and number of injections. RNFL thickness (overall and by quadrant) was measured at baseline and one-year follow-up. Additional outcomes included IOP, visual acuity (VA), and central retinal thickness (CRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The matched cohort had a mean age of 71.06\u202f\u00b1\u202f11.44 years, with 61.4% female participants. ACP eyes had worse baseline VA, higher IOP, and thicker CRT (p\u2009&lt;\u20090.050, for all), but showed greater VA improvement (p\u2009=\u20090.023) and a trend towards greater CRT reduction (p\u2009=\u20090.061). RNFL thinning over one year did not differ between the groups (\u22123.24\u2009\u00b1\u200911.82\u2005\u00b5m vs \u22122.95\u2009\u00b1\u20097.81\u2005\u00b5m, p\u2009=\u20090.883). No major complications were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ACP did not significantly reduce RNFL thinning over one year but was well tolerated. It may be considered in patients at higher risk from transient IOP elevations. Future prospective studies are warranted to clarify its role in specific patient subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251389427","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T02:38:09Z","timestamp":1761273489000},"page":"677-685","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["To ac tap or not to ac tap: Multi-centre outcomes of patients receiving anti-VEGF injections"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-3288","authenticated-orcid":false,"given":"Michael","family":"Ostrovsky","sequence":"first","affiliation":[{"name":"Hebrew University of Jerusalem"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raman","family":"Tuli","sequence":"additional","affiliation":[{"name":"University of Ottawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Kozlov","sequence":"additional","affiliation":[{"name":"The Hebrew University of Jerusalem"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C W","family":"Robart","sequence":"additional","affiliation":[{"name":"Memorial University of Newfoundland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0491-9263","authenticated-orcid":false,"given":"Sunil","family":"Ruparelia","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Lebreton","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Sherbrooke"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Gou","sequence":"additional","affiliation":[{"name":"Memorial University of Newfoundland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6386-2116","authenticated-orcid":false,"given":"Nir","family":"Shoham-Hazon","sequence":"additional","affiliation":[{"name":"Dalhousie University Nova Scotia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Kin Man","family":"Lee","sequence":"additional","affiliation":[{"name":"Memorial University of Newfoundland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efraim","family":"Berco","sequence":"additional","affiliation":[{"name":"Hebrew University of 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