{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:49:00Z","timestamp":1793904540604,"version":"4.8.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2024YFE0198100"],"award-info":[{"award-number":["2024YFE0198100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"General Program of National Natural Science Foundation of China","award":["82272086"],"award-info":[{"award-number":["82272086"]}]},{"name":"Shenzhen Medical Research Fund","award":["D2402014"],"award-info":[{"award-number":["D2402014"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate iris melanin concentration using polarization-sensitive anterior segment optical coherence tomography (PS-AS-OCT) and to explore its correlation with iris color in individuals with brown irides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Iris cross-sectional images were acquired using PS-AS-OCT. Substructural layers were automatically segmented using a deep learning model. The melanin concentration ratio (MCR) was derived from entropy-based PSAS-OCT images to quantify melanin within the iris layers. Iris surface color was analyzed using CIE L*a*b* values from high-resolution photographs. Correlation analyses were performed between MCR and L*a*b* values. Additionally, a three-grade iris color classification was used, and K-nearest neighbors (KNN) modeling assessed the predictive value of MCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty-eight participants (mean age: 39 years) were included. MCR of the iris stroma showed a strong negative correlation with iris color: L* (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.72), a* (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009\u20130.56), and b* (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009\u20130.68), all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001. Stromal MCR significantly differed among color grades (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and the KNN model achieved 85% classification accuracy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PS-AS-OCT\u2013derived stromal MCR is strongly associated with iris color and offers a noninvasive approach for evaluating iris melanin. This technique may provide new insights into ocular pigmentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251407025","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T15:20:49Z","timestamp":1766503249000},"page":"872-880","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative measurement of Iris melanin concentration by polarization-sensitive anterior segment optical coherence tomography"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-9044","authenticated-orcid":false,"given":"Xiaoling","family":"Li","sequence":"first","affiliation":[{"name":"Southern University of Science and Technology"},{"name":"School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxi","family":"Hu","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yang","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunjie","family":"Xiao","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamanari","sequence":"additional","affiliation":[{"name":"Tomey Corporation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Higashita","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology"},{"name":"Tomey Corporation"},{"name":"Department of Electronic and Information Engineering, Changchun University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology"},{"name":"School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Department of Electronic and Information Engineering, Changchun University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-2006-8"},{"key":"e_1_3_3_3_2","first-page":"872","article-title":"Iris color and associated pathological ocular complications: a review of epidemiologic studies","volume":"7","author":"Sun H-P","year":"2014","unstructured":"Sun H-P, Lin Y, Pan C-W. Iris color and associated pathological ocular complications: a review of epidemiologic studies. Int J Ophthalmol 2014; 7: 872\u2013878.","journal-title":"Int J Ophthalmol"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01749-x"},{"key":"e_1_3_3_5_2","first-page":"29","article-title":"IRIS COLOUR CLASSIFICATION SCALES\u2013THEN AND NOW","volume":"59","author":"Grigore M","year":"2015","unstructured":"Grigore M, Avram A. IRIS COLOUR CLASSIFICATION SCALES\u2013THEN AND NOW. 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