{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:19:59Z","timestamp":1777580399283,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of this study was to analyze retinal changes using optical coherence tomography angiography (OCTA) in Macular Telangiectasia type-2 (MacTel-2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 65 MacTel-2 patients (122 eyes) and 65 age- and sex-matched healthy controls (122 eyes). All participants had complete examination notes with fundus autofluorescence, fluorescein angiography, optical coherence tomography, and OCTA. Foveal avascular zone (FAZ) parameters, vascular densities (VDs), and retinal thicknesses (RT) of MacTel-2 patients were compared with healthy eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Acircularity index (AI) and the FAZ perimeter were significantly higher in the MacTel-2 group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.04). There was a positive correlation between AI and logMAR (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.287,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001). VDs in the foveal and perifoveal temporal quadrants of the superficial capillary plexus were lower in the MacTel-2 group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.021). VDs in the foveal and all parafoveal regions of the deep capillary plexus (DCP) were also decreased compared with the control group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for all). Additionally, the mean RT in the fovea and all parafoveal regions was significantly lower in MacTel-2 patients compared to controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vascular density changes in MacTel-2 is seen more frequently in the DCP. Additionally, acircularity index showed a steady worsening with disease progression, suggesting its potential use as a marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721251407842","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:42:17Z","timestamp":1765816937000},"page":"686-697","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinal microvascular alterations in macular telangiectasia type 2: An optical coherence tomography angiography study"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-7937","authenticated-orcid":false,"given":"G\u00fcl\u015fah","family":"G\u00f6kg\u00f6z","sequence":"first","affiliation":[{"name":"Ba\u015fkent University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1745-7341","authenticated-orcid":false,"given":"G\u00fcven","family":"G\u00f6kg\u00f6z","sequence":"additional","affiliation":[{"name":"Republic of Turkiye, Ministry of Health, General Directorate of Public Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-3781","authenticated-orcid":false,"given":"Zeynep Eyl\u00fcl","family":"Ercan","sequence":"additional","affiliation":[{"name":"Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Yenimahalle Education and Training Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-7424","authenticated-orcid":false,"given":"\u0130mren","family":"Akkoyun","sequence":"additional","affiliation":[{"name":"Ba\u015fkent University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcrsel","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Ba\u015fkent University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2012.11.002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.4.450"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307941"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/09286580903450361"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.03.021"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31447-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.11.007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000256663.94734.e1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.08.016"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002510"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.10.1410"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.galenos.2021.75608"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2019.1673437"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.08.028"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0432-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.3616"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/12583_14"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20140909-06"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.115485"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000310399"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001694"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27055"},{"key":"e_1_3_2_24_2","article-title":"Quantitative analysis of retinal microvascular changes in macular telangiectasia type 2 using optical coherence tomography angiography","volume":"15","author":"Park YG","year":"2020","unstructured":"Park YG, Park YH. Quantitative analysis of retinal microvascular changes in macular telangiectasia type 2 using optical coherence tomography angiography. 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