{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:20:45Z","timestamp":1787160045442,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Science","doi-asserted-by":"crossref","award":["KL2 TR002379"],"award-info":[{"award-number":["KL2 TR002379"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the relationship between systemic comorbidities and presenting tumor T category in patients with uveal melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single-center, retrospective cohort study of patients with posterior uveal melanoma initially diagnosed between January 2000 and December 2016. Univariate and multivariate ordinal logistic regression analyses were performed to identify comorbidities associated with presenting tumor T category, as classified by AJCC criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Initial presenting AJCC T category was T1 in 190 (43%), T2 in 130 (29%), T3 in 89 (20%), and T4 in 38 (9%). The most common comorbidities present were hypertension (250 patients, 56%), hyperlipidemia (211, 47%), obesity (137, 31%), and diabetes mellitus (87, 19%). Of these, obesity (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.034), hypertension (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.017), and diabetes mellitus (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were associated with earlier presenting T category on univariate ordinal logistic regression. After multivariate regression, only diabetes mellitus (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.01) and obesity (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.04) remained significantly associated with earlier T category on initial presentation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients presenting with uveal melanoma, diabetes mellitus and obesity were associated with earlier presenting T category, which could reflect earlier detection of uveal melanoma in patients undergoing annual diabetic retinopathy screening examinations or having more frequent contact with the healthcare system. Larger studies should further explore this association and examine the utility of increased ocular screening in early detection of uveal melanoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721261419674","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:15:48Z","timestamp":1770228948000},"page":"1007-1014","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Diabetes mellitus is associated with earlier detection of posterior uveal melanoma"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3262-3808","authenticated-orcid":false,"given":"Richard T","family":"Roden","sequence":"first","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6813-5492","authenticated-orcid":false,"given":"Robert A","family":"Churchill","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-0062","authenticated-orcid":false,"given":"Blake H","family":"Fortes","sequence":"additional","affiliation":[{"name":"University of California"},{"name":"Stein Eye Institute, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Launia J","family":"White","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O","family":"Hodge","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela E","family":"Madira","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin J","family":"Myrah","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9710-4284","authenticated-orcid":false,"given":"Lauren A","family":"Dalvin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S89591"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.3881"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.208"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11547-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.355"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0249-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200502000-00006"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.246"},{"key":"e_1_3_3_10_2","first-page":"337","article-title":"The impact of comorbidity on cancer and its treatment","volume":"66","author":"Sarfati D","unstructured":"Sarfati D, Koczwara B, Jackson C. 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