{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:50:45Z","timestamp":1781923845680,"version":"3.54.5"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the impact of eyelid hygiene on conjunctival microbial species and ocular discharge in patients with ocular prostheses(OP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective study included patients with unilateral anophthalmic sockets or phthisis bulbi using OP. Two visits were scheduled: baseline and 7 days later. At each visit, three samples were collected: lower tarsal conjunctiva of the affected eye, bulbar conjunctiva of the affected eye, and lower tarsal conjunctiva of the healthy eye. Patients followed one of two hygiene regimens: Ozonest\n                      <jats:sup>\u00ae<\/jats:sup>\n                      group (wipes and liposomal-ozonated-oil drops) or Lephanet\n                      <jats:sup>\u00ae<\/jats:sup>\n                      group (wipes and saline solution). Demographic data, clinically significant discharge(CSD), and eyelid cleaning habits were recorded. Statistical significance was set at P\u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-one patients (mean age 63.7\u2009\u00b1\u200915.5 years, 54.1% male) contributed 366 samples. 31 (50.8%) were in Ozonest and 30(49.2%) in Lephanet. Staphylococcus epidermidis (39%) and Corynebacterium macginleyi (24.6%) were most common. Positive cultures were higher in affected eyes (78.7%) than in healthy eyes (32.8%, P\u2009&lt;\u20090.05). Tarsal conjunctiva cultures decreased with both Ozonest(64.5% to 51.6%) and Lephanet (56.7% to 46.7%). Overall CSD decreased from 47.5% to 16.4%, particularly in Lephanet (60% to 10%, P\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Positive cultures were more frequent in prosthetic eyes than in healthy eyes being with\n                      <jats:italic toggle=\"yes\">S. epidermidis<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">C. macginleyi<\/jats:italic>\n                      being the most frequent microorganisms. Both hygiene regimens reduced positive tarsal conjunctival cultures and improved CSD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721261422829","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T17:53:11Z","timestamp":1771437191000},"page":"1023-1032","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of eyelid hygiene on conjunctival microbial species and ocular discharge in patients with ocular prostheses"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-0784","authenticated-orcid":false,"given":"Irene","family":"Bermudez-Castellanos","sequence":"first","affiliation":[{"name":"Rio Hortega University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3111-3898","authenticated-orcid":false,"given":"Daniel","family":"Padilla-Pantoja","sequence":"additional","affiliation":[{"name":"Rio Hortega University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-0622","authenticated-orcid":false,"given":"M\u00f3nica","family":"Frutos Serna","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Rio Hortega University Hospital, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-7794","authenticated-orcid":false,"given":"Hortensia","family":"S\u00e1nchez Tocino","sequence":"additional","affiliation":[{"name":"Rio Hortega University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-2254","authenticated-orcid":false,"given":"Victoria","family":"Marqu\u00e9s Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Rio Hortega University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6914-9987","authenticated-orcid":false,"given":"Marta","family":"Hernandez","sequence":"additional","affiliation":[{"name":"University of Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5357-6340","authenticated-orcid":false,"given":"Jose Maria","family":"Eiros Bouza","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Rio Hortega University Hospital, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8854-9625","authenticated-orcid":false,"given":"Alicia","family":"Galindo-Ferreiro","sequence":"additional","affiliation":[{"name":"Rio Hortega University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"47","article-title":"Concerns of anophthalmic patients wearing artificial eyes","volume":"39","author":"Pine K","year":"2011","unstructured":"Pine K, Sloan B, Stewart J, et al. 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