{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:50:57Z","timestamp":1781923857625,"version":"3.54.5"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the dynamics of retinal fluid in eyes compromised by exudative macular neovascularization beneath the retinal pigment epithelium (MNV type 1) secondary to neovascular age-related macular degeneration (nAMD) and its impact on disease control over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective single center study, 65 eyes of 65 patients with treatment-naive exudative MNV Type 1 were analyzed for the presence of subretinal fluid (SRF) and intraretinal fluid (IRF) in structural OCT B-scans for three years. All eyes started on three monthly intravitreal anti-VEGF injections followed by a personalized treatment interval. Primary outcome measure was visual acuity score (VAS) change based on fluid dynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      29 (45%) eyes with SRF only started with a VAS of 74\u2009\u00b1\u20099 letters ETDRS, 20 eyes (31%) with SRF in the beginning that developed additional IRF had an initial VAS of 68\u2009\u00b1\u200911 letters, and 16 eyes (25%) with both, SRF and IRF measured 63\u2009\u00b1\u200913 letters at presentation. The VAS of all patients declined significantly (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003) over time, but no significant VAS change was measured between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IRF was regarded as a negative predictive OCT biomarker towards a lower VAS at the beginning but not necessarily during the course of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721261424054","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:05:05Z","timestamp":1772111105000},"page":"954-962","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of fluid on visual acuity in exudative macular neovascularization type 1: A long-term real-life AMD study"],"prefix":"10.1177","volume":"36","author":[{"given":"Michael","family":"Jacob","sequence":"first","affiliation":[{"name":"Karl Landsteiner Institute for Retinal Research and Imaging, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"},{"name":"Department of Ophthalmology, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3081-9311","authenticated-orcid":false,"given":"Martin","family":"Stattin","sequence":"additional","affiliation":[{"name":"Karl Landsteiner Institute for Retinal Research and Imaging, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"},{"name":"Department of Ophthalmology, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Graf","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Ebner","sequence":"additional","affiliation":[{"name":"Karl Landsteiner Institute for Retinal Research and Imaging, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"},{"name":"Department of Ophthalmology, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ahmed-Balestra","sequence":"additional","affiliation":[{"name":"Karl Landsteiner Institute for Retinal Research and Imaging, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"},{"name":"Department of Ophthalmology, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Krepler","sequence":"additional","affiliation":[{"name":"Karl Landsteiner Institute for Retinal Research and Imaging, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"},{"name":"Department of Ophthalmology, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8032-4686","authenticated-orcid":false,"given":"Siamak","family":"Ansari-Shahrezaei","sequence":"additional","affiliation":[{"name":"Karl Landsteiner Institute for Retinal Research and Imaging, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"},{"name":"Department of Ophthalmology, Clinic Landstra\u00dfe, Vienna Healthcare Group, Vienna, Austria"},{"name":"Medical School, Sigmund Freud University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004664"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01713-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00063-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.07.006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.11.004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181e7976b"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054481"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.09.016"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2017.03.015"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01487-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9994098"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6695918"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8345850"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.03.037"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.199216"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.018"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-015-0015-6"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.11.025"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003180"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.07.007"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.06.003"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.12.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2024-325640"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2022.03.024"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.11.017"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.047"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.006"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.03.045"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2018.01.005"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-317326"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004054"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.02.019"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-023-00727-8"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.11.007"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2007.02.008"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2025.09.017"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2023.10.006"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0288861"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.66.9.19"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1177\/11206721241282429"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002870"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721261424054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721261424054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721261424054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:01:55Z","timestamp":1781920915000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721261424054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/11206721261424054"],"URL":"https:\/\/doi.org\/10.1177\/11206721261424054","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}