{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:18:51Z","timestamp":1787653131464,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Optic disc melanocytoma is a rare, typically benign pigmented tumor that may occasionally lead to vision loss or tumor enlargement. Despite its usually indolent nature, the clinical behavior and risk factors associated with progression remain incompletely defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted involving 21 patients diagnosed with optic disc melanocytoma at Sheba Medical Center, Israel, between 2009 and 2024. Data were collected on demographics, presenting symptoms, imaging characteristics, and visual outcomes. Tumor features were analyzed using fundus photography, optical coherence tomography (OCT), and B-scan ultrasonography. Statistical tests were performed to explore associations between tumor behavior and clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort had a mean age of 60.1 years; Fourteen (66.7%) were female. Most tumors appeared flat and were located inferiorly or nasally. Over a mean follow-up of 64 months, five (23.8%) patients exhibited measurable tumor growth, with one case (4.7%) resulting in severe visual decline. Vision loss of two or more Snellen lines was significantly associated with floaters at presentation (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.04), optic disc edema (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002), and pigmented vitreous seeds (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.04). No significant associations were found with demographic or iris pigmentation variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While optic disc melanocytoma typically follows a benign course, certain clinical features\u2014such as floaters, disc edema, and vitreous seeding\u2014may indicate a higher risk for tumor progression and vision loss. These findings highlight the importance of targeted surveillance strategies in patients presenting with these features to facilitate early detection and optimized management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721261441072","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:57:11Z","timestamp":1775743031000},"page":"1418-1424","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A cohort study of melanocytoma of the optic disc in the Israeli population: Factors associated with vision loss"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1108-3430","authenticated-orcid":false,"given":"Konstantin Y","family":"Gushansky","sequence":"first","affiliation":[{"name":"Assuta Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Stanescu","sequence":"additional","affiliation":[{"name":"Assuta Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicktoria","family":"Vishnevskia-Dai","sequence":"additional","affiliation":[{"name":"Sheba Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.02.016"},{"key":"e_1_3_2_3_2","article-title":"Optic disk melanocytoma and optical coherence tomography angiography OCT-A","author":"Parra MM","year":"2023","unstructured":"Parra MM, Yan J, Hsu J, et al. Optic disk melanocytoma and optical coherence tomography angiography OCT-A. Am Acad Ophthalmol 2023, https:\/\/eyewiki.aao.org\/Optic_Disk_Melanocytoma_and_Optical_Coherence_Tomography_Angiography_OCT-A (accessed 2 April 2025).","journal-title":"Am Acad Ophthalmol"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1933.00830010582006"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_2039_19"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181dd0bd3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197172"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.6.811"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000453110"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(99)00065-3"},{"key":"e_1_3_2_11_2","first-page":"296","article-title":"Clinical manifestation and follow-up of melanocytoma of the optic disc","volume":"45","author":"Zhang CF","year":"2009","unstructured":"Zhang CF, Dong FT, Chen YX, et al. Clinical manifestation and follow-up of melanocytoma of the optic disc. Zhonghua Yan Ke Za Zhi 2009; 45: 296\u2013300. PMID: 19951540, https:\/\/pubmed.ncbi.nlm.nih.gov\/19575959\/.","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.07.004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.11.048"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.65488"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000134"},{"key":"e_1_3_2_16_2","first-page":"33","article-title":"Melanocytoma inducing compressive optic neuropathy: the ocular morbidity potential of an otherwise invariably benign lesion","volume":"73","author":"Besada E","year":"2002","unstructured":"Besada E, Shechtman D, Barr RD. Melanocytoma inducing compressive optic neuropathy: the ocular morbidity potential of an otherwise invariably benign lesion. Optometry 2002; 73: 33\u201338. PMID: 11822150, https:\/\/pubmed.ncbi.nlm.nih.gov\/12363236\/.","journal-title":"Optometry"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820530701457209"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000310133"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-019-04257-7"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.1502"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.36.8.447"},{"key":"e_1_3_2_22_2","first-page":"129","article-title":"Central retinal vascular obstruction secondary to melanocytoma of the optic disc","volume":"119","author":"Shields JA","year":"2001","unstructured":"Shields JA, Shields CL, Eagle RCJr, et al. Central retinal vascular obstruction secondary to melanocytoma of the optic disc. Arch Ophthalmol 2001; 119: 129\u2013133, https:\/\/jamanetwork.com\/journals\/jamaophthalmology\/fullarticle\/264778.","journal-title":"Arch Ophthalmol"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200504000-00019"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4927"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S80152"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(90)32601-5"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(88)90164-6"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721261441072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721261441072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721261441072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:25:02Z","timestamp":1787649902000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721261441072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/11206721261441072"],"URL":"https:\/\/doi.org\/10.1177\/11206721261441072","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]}}}