{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:18:52Z","timestamp":1787653132464,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Pregnancy induces hormonal changes that can affect various organ systems, including ocular structures. This study aimed to evaluate changes in anterior segment (AS) parameters, higher-order aberrations (HOAs), and aqueous humour (AH) optical density (OD) in pregnant women compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective case\u2013control study included 45 healthy pregnant women and 47 age-matched non-pregnant controls. Comprehensive ophthalmological examinations were performed, including best-corrected visual acuity (BCVA), intraocular pressure, spherical equivalent, axial length, central corneal thickness, corneal volume, corneal curvature (K1, K2, Km), AS parameters, and endothelial cell metrics. HOAs (coma, trefoil, spherical aberration) and AH OD were also assessed. Ocular surface evaluations included the OSDI questionnaire, Schirmer test and tear break-up time. Pregnant participants were assessed in each trimester and three months postpartum, with comparisons conducted both cross-sectionally against healthy controls and longitudinally within the pregnancy cohort across trimesters and postpartum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RMS-HOA was higher in the third trimester (0.41\u2009\u00b1\u20090.19\u2005\u00b5m,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003) and postpartum (0.39\u2009\u00b1\u20090.31\u2005\u00b5m,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.041). RMS-total increased in the second (1.64\u2009\u00b1\u20090.21\u2005\u00b5m,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.031) and third trimesters (1.63\u2009\u00b1\u20090.46\u2005\u00b5m,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.022). Coma was higher in the second (1.64\u2009\u00b1\u20090.34\u2005\u00b5m,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.045) and third trimesters (1.61\u2009\u00b1\u20090.29\u2005\u00b5m,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.040), and trefoil increased in the third trimester (1.50\u2009\u00b1\u20090.35\u2005\u00b5m,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.027). AH OD was higher than in controls at every time point, measuring 4.74\u2009\u00b1\u20090.41% in the first trimester (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.007), 4.81\u2009\u00b1\u20090.50% in the second (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001), 4.96\u2009\u00b1\u20090.42% in the third (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001), and 4.79\u2009\u00b1\u20090.46% postpartum (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.020). BCVA was unchanged.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In pregnancy, small increases in HOAs and AH OD are typically subclinical and reflect physiological change rather than pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721261441666","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T13:04:24Z","timestamp":1775826264000},"page":"1244-1253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in anterior segment, ocular aberrations, and aqueous humour density during pregnancy and postpartum"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8761-6104","authenticated-orcid":false,"given":"Yusuf Samet","family":"Atlihan","sequence":"first","affiliation":[{"name":"Akdeniz University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4463-0883","authenticated-orcid":false,"given":"Ali","family":"Pota","sequence":"additional","affiliation":[{"name":"Antalya Kepez State Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7581-594X","authenticated-orcid":false,"given":"Do\u011fa Akay","family":"Saliho\u011flu","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Antalya Training and Research Hospital, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-4573","authenticated-orcid":false,"given":"G\u00fcl Alkan","family":"B\u00fclb\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology, Antalya Training and Research Hospital, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2021.1896748"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00569.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2013.874479"},{"key":"e_1_3_2_5_2","first-page":"256","article-title":"The effect of pregnancy on corneal curvature","volume":"18","author":"Park SB","year":"1992","unstructured":"Park SB, Lindahl KJ, Temnycky GO, et al. 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