{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:18:46Z","timestamp":1787653126365,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study assessed retinal non-perfusion areas (RNPAs) and vascular density (VD) in the superficial (SCP) and deep (DCP) capillary plexuses of diabetic patients across three stages of diabetic retinopathy (DR): no DR (stage 0), non-proliferative DR (stage 1), and proliferative DR (stage 2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-nine right eyes of 39 diabetic patients were included and underwent 3\u2009\u00d7\u20093\u2005mm and 15\u2009\u00d7\u200915\u2005mm Optical Coherence Tomography Angiography (OCTA) scans. A semiautomated software was utilized to quantify RNPAs and VD. Correlations with systemic and ocular factors were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six eyes were in stage 0, 25 eyes were in stage 1 and 8 eyes were in stage 2. Mean RNPAs and VD from 15\u2009\u00d7\u200915\u2005mm OCTA scans differed significantly across the three DR stages. A positive correlation was found between DR stage and RNPA in both SCP (CC\u2009=\u20090.42;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.04) and DCP (CC\u2009=\u20090.60;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.004). Conversely, VD in DCP was negatively correlated with DR severity (CC\u2009=\u2009\u22120.51;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0018). Eyes with prior peripheral laser treatment showed significantly larger RNPAs and lower VD in wide-field scans. Macular edema was associated with increased RNPA and reduced VD in the SCP on 3\u2009\u00d7\u20093\u2005mm OCTA (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      's\u2009&lt;\u20090.001). No significant associations were observed between OCTA parameters and systemic factors (e.g., hypertension, nephropathy).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Semiautomated OCTA analysis of retinal ischemia correlates positively with DR stage, peripheral laser treatment, and macular edema. The lack of association with systemic factors highlights the critical role of local ocular changes in DR progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721261444772","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:02:45Z","timestamp":1776776565000},"page":"1391-1399","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Semiautomatic analysis of retinal ischemia using widefield OCTA in patients with diabetes mellitus with or without diabetic retinopathy"],"prefix":"10.1177","volume":"36","author":[{"given":"Toto","family":"Lisa","sequence":"first","affiliation":[{"name":"University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiarelli Antonio","family":"Maria","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University G. D\u2019Annunzio Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5208-1263","authenticated-orcid":false,"given":"Belloni Baroni","family":"Luca","sequence":"additional","affiliation":[{"name":"University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Passamonti","family":"Marzia","sequence":"additional","affiliation":[{"name":"University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-6124","authenticated-orcid":false,"given":"Quarta","family":"Alberto","sequence":"additional","affiliation":[{"name":"University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggeri Maria","family":"Ludovica","sequence":"additional","affiliation":[{"name":"University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5383-5173","authenticated-orcid":false,"given":"D\u2019Aloisio","family":"Rossella","sequence":"additional","affiliation":[{"name":"AUSL Pescara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mastropasqua","family":"Rodolfo","sequence":"additional","affiliation":[{"name":"\u201cG. d\u2019Annunzio\u201d University Chieti-Pescara"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v14.i4.95881"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-021-01844-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20181203-01"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2017.09.011"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2024.100603"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2022.100144"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316245"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.06.022"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-023-02882-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000523749"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.7.13"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13099"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01410-w"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-311942"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S79448"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.07.034"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300774"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2019.0440"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-022-02508-6"},{"key":"e_1_3_3_21_2","first-page":"205","article-title":"Macular ischaemia as a marker for nephropathy in diabetic retinopathy","volume":"52","author":"Shukla D","year":"2004","unstructured":"Shukla D, Kolluru CM, Singh J, et al. 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