{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:45:03Z","timestamp":1793022303872,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To identify predictors of unplanned endothelial keratoplasty after phacoemulsification in Fuchs\u2019 endothelial corneal dystrophy (FECD), and to assess postoperative best-corrected visual acuity (BCVA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective single-centre case series of 50 eyes (39 patients) that underwent soft-shell phacoemulsification and monofocal intra-ocular lens implantation by one surgeon (2015\u20132021). The primary outcome was unplanned corneal decompensation requiring endothelial keratoplasty. Associations with specular-microscopy parameters and central corneal thickness (CCT) were examined with penalised logistic and Cox regressions adjusted for age, sex, and hypertonic-saline use. Postoperative BCVA was analysed using linear regression models also adjusted for baseline acuity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age was 74\u2009\u00b1\u20098 years; 68% were women; median follow-up 32 (IQR 24\u201340) months. Four eyes (8%) required Descemet stripping endothelial keratoplasty a median 8 months after cataract surgery. Each 1\u2005\u03bcm increase in pre-operative CCT raised the hazard of grafting by 2% (HR 1.02, 95% CI 1.00\u20131.04,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.031); a threshold of\u2009\u2265\u2009620\u2005\u03bcm yielded an AUC of 0.91. Linear regression analyses of postoperative BCVA adjusted for preoperative BCVA showed no clear association between baseline and postoperative acuity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre-operative CCT shows the strongest association of readily available metrics with post-phaco corneal failure in FECD; values above \u223c600\u2005\u03bcm may warrant counselling regarding combined or staged keratoplasty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721261445518","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:07:55Z","timestamp":1781788075000},"page":"1568-1574","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Soft-shell phacoemulsification in Fuchs\u2019 endothelial dystrophy: Central corneal thickness as a predictor of post-operative keratoplasty"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-0233","authenticated-orcid":false,"given":"Boon Lin","family":"Teh","sequence":"first","affiliation":[{"name":"Royal Victoria Infirmary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Tzoumas","sequence":"additional","affiliation":[{"name":"Royal Victoria Infirmary"},{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza Mylla","family":"Boso","sequence":"additional","affiliation":[{"name":"Royal Victoria Infirmary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Lin","family":"Ang","sequence":"additional","affiliation":[{"name":"Royal Victoria Infirmary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Papadakou","sequence":"additional","affiliation":[{"name":"Royal Victoria Infirmary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-288X","authenticated-orcid":false,"given":"Francisco C.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Royal Victoria Infirmary"},{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100863"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.4776"},{"key":"e_1_3_3_4_2","first-page":"295","article-title":"REVIEW: current understanding of the pathogenesis of Fuchs\u2019 endothelial corneal dystrophy","volume":"25","author":"Nanda GG","year":"2019","unstructured":"Nanda GG, Alone DP. REVIEW: current understanding of the pathogenesis of Fuchs\u2019 endothelial corneal dystrophy. Mol Vision 2019; 25: 295\u2013310.","journal-title":"Mol Vision"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70232-X"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000816"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S338001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2018.08.005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)80121-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)01251-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.06.011"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.06.049"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(02)01323-8"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2011.05.039"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.10.044"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopthalmol.2011.1626"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1978.03910060424004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002855"},{"key":"e_1_3_3_19_2","first-page":"321","article-title":"Fuchs endothelial corneal dystrophy: current perspectives","volume":"10","author":"Vedana G","year":"2016","unstructured":"Vedana G, Villarreal Jr G, Jun AS. Fuchs endothelial corneal dystrophy: current perspectives. Clinical Ophthalmology (Auckland, NZ) 2016; 10: 321\u2013330.","journal-title":"Clinical Ophthalmology (Auckland, NZ)"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.07.005"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.07.012"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200308000-00005"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.09.047"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2019.1632355"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15691"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.08.006"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2021.05.07"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721261445518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721261445518","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721261445518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:11:11Z","timestamp":1793020271000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721261445518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1177\/11206721261445518"],"URL":"https:\/\/doi.org\/10.1177\/11206721261445518","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}