{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T18:34:06Z","timestamp":1788719646916,"version":"build-2803163510"},"reference-count":48,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To systematically evaluate retinal and choroidal structural alterations measured by optical coherence tomography (OCT) in individuals with a history of retinopathy of prematurity (ROP) compared with healthy controls, and to identify sources of heterogeneity across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PROSPERO-registered systematic review (CRD42023422605) was conducted in accordance with PRISMA guidelines. PubMed, Scopus, and EMBASE were searched from inception through July 26, 2023. Human observational studies reporting OCT-derived retinal or choroidal thickness metrics in ROP with healthy controls were included. Random-effects meta-analyses were performed using standardized mean differences (SMD) and weighted mean differences. Meta-regression and subgroup analyses explored heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven studies (1,019 participants; 351 ROP, 668 controls) were included. Compared with controls, eyes with ROP demonstrated significantly thinner macular ganglion cell\u2013inner plexiform layer (GCIPL) thickness (SMD \u22121.07;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002) and thinner superior and temporal perifoveal retina, alongside significantly increased foveal retinal thickness (SMD 1.41;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). No significant difference was observed in subfoveal choroidal thickness. Substantial heterogeneity was present across most outcomes (I\n                      <jats:sup>2<\/jats:sup>\n                      frequently &gt;75%). Meta-regression identified younger age at imaging as significantly associated with greater foveal thickening (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002). OCT platform and geographic location also contributed to variability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individuals with prior ROP exhibit persistent, layer-specific and region-specific macular alterations consistent with disrupted neurovascular development and foveal hypoplasia. However, substantial methodological heterogeneity limits transportability of thickness-based biomarkers. Standardized, age-aware prospective OCT studies are required before structural metrics can be adopted for clinical risk stratification or longitudinal surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721261445530","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:33:51Z","timestamp":1777296831000},"page":"1175-1185","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Optical coherence tomography measurements in retinopathy of prematurity: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2114-9207","authenticated-orcid":false,"given":"Sayena","family":"Jabbehdari","sequence":"first","affiliation":[{"name":"University of Illinois at Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-6824","authenticated-orcid":false,"given":"Sepehr","family":"Fekrazad","sequence":"additional","affiliation":[{"name":"Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Oganov","sequence":"additional","affiliation":[{"name":"Stony Brook University Hospital, Renaissance School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem","family":"Yazdanpanah","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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