{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:39:53Z","timestamp":1793021993930,"version":"4.5.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare geographic atrophy (GA) growth in eyes with and without macular neovascularization (MNV) and evaluate anti-VEGF therapy effects on GA progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One eye per patient with GA with one-year of follow-up was included. Patients who developed MNV in previously diagnosed GA were assigned to the MNV-GA group, while those who did not were assigned to the non-MNV group. OCT determined MNV location and type. GA was quantified from RPE en-face images using ImageJ over one year. Fellow eyes were followed to last visit. Analyses used SPSS with Mann\u2013Whitney U;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05 denoted significance, and prespecified thresholds applied throughout analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 60 eyes from 60 patients were included (mean age: 82.75\u2009\u00b1\u20097.31; 56.7% female). A significant difference in GA area growth over one year was observed between two groups, with slower GA enlargement in MNV-GA group (1.15\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      vs. 2.36\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001; and square root: 0.38\u2009\u00b1\u20090.28 vs. 0.46\u2009\u00b1\u20090.36;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.040). In MNV-GA eyes, GA growth showed no correlation with the number of anti-VEGF injections (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.692). Most MNVs were type 1 (46.7%) and type 2 (43.3%) and were predominantly located at the GA border (70.0%), particularly in the central (30.0%) and superior (30.0%) sectors. Among the 60 fellow-eyes, 27 (45.0%) developed MNV during follow-up. Of these, 25 eyes (83.3%) were from patients from MNV-GA group, whereas only 2 eyes (6.7%) were from non-MNV group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eyes with MNV-GA showed slower GA enlargement over one-year, regardless of anti-VEGF frequency, and higher fellow-eye MNV risk, indicating shared risk factors but distinct mechanisms influencing disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721261461910","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:26:32Z","timestamp":1783340792000},"page":"1723-1730","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct interactions between macular neovascularization and geographic atrophy: Growth dynamics and fellow-eye risk"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3802-3219","authenticated-orcid":false,"given":"Elham","family":"Sadeghi","sequence":"first","affiliation":[{"name":"University of Pittsburgh, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Gregori","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine"},{"name":"Polytechnic University of Marche"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"DeCicco","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-2450","authenticated-orcid":false,"given":"Priyanka","family":"Gandhi","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep Chandra","family":"Bollepalli","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran Kumar","family":"Vupparaboina","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Alain","family":"Sahel","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-5460","authenticated-orcid":false,"given":"Andrew W","family":"Eller","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of 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