{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T14:44:41Z","timestamp":1782657881179,"version":"3.54.5"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To characterize the spatiotemporal patterns of vascular remodeling following pterygium excision with amniotic membrane transplantation (AMT) using optical coherence tomography angiography (OCTA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational study evaluated 43 eyes undergoing AMT. Serial OCTA imaging was performed over a 12-week postoperative period to quantify vascular dynamics in superficial and deep conjunctival layers. Quantitative parameters, including vessel density (VD), vessel length density (VLD), and vessel diameter index (VDI), were analyzed using automated image processing techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Early assessment at Week 1 showed minimal vascular in-growth. By Week 4, progressive remodeling was evident, primarily driven by deep-layer anastomoses between host tissue and the graft area. By Week 12, a structured vascular network emerged; however, superficial perfusion remained significantly reduced compared to baseline. While deep-layer VD demonstrated substantial recovery, VDI remained statistically stable. Notably, OCTA identified persistent flow voids and heterogeneous perfusion, suggesting irregular host-derived vascular integration beneath the graft.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post-AMT healing is mediated predominantly by deep-layer episcleral vascular remodeling. OCTA serves as a sensitive, non-invasive tool for monitoring subclinical vascular integration, offering potential biomarkers for surgical success and early pterygium recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721261462633","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:16:07Z","timestamp":1782389767000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of post-operative changes after pterygium surgery with amniotic membrane transplantation using optical coherence tomography angiography (OCTA)"],"prefix":"10.1177","author":[{"given":"Amirhossein","family":"Hashemi","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3568-3192","authenticated-orcid":false,"given":"Seyedeh Zahra","family":"Seyedi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazal","family":"Ghochani","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Soleimanzadeh","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Nazari","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haniyeh","family":"Zeidabadinejad","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Ghanbari","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Montazeriani","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences and Research Center for Science and Technology in Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Sanei","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-0821","authenticated-orcid":false,"given":"Ahmad","family":"Masoumi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.01.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100160405001"},{"key":"e_1_3_2_4_2","first-page":"73","article-title":"Observation of long-term efficacy of corneal limbal conjunctival autografts in microscopy treatments of pterygium","volume":"28","author":"Yang Y","year":"2013","unstructured":"Yang Y, Pi M, Xu F. Observation of long-term efficacy of corneal limbal conjunctival autografts in microscopy treatments of pterygium. Eye Sci 2013; 28: 73\u201378.","journal-title":"Eye Sci"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001407"},{"key":"e_1_3_2_6_2","first-page":"243","article-title":"Amniotic membrane transplantation in the human eye","volume":"108","author":"Meller D","year":"2011","unstructured":"Meller D, Pauklin M, Thomasen H, et al. Amniotic membrane transplantation in the human eye. Dtsch Arztebl Int 2011; 108: 243\u2013248. 20110408.","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-018-0784-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13094"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15288"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.04.002"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.66.13.3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-019-0129-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2018.1438630"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.07.024"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.08.009"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2025-327973"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.04.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/9479183"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62607-6"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.02.006"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-0773-8"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1034_20"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/039463201202500307"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/25158414211020152"},{"key":"e_1_3_2_25_2","first-page":"1762","article-title":"Glaucoma filtration surgery using amniotic membrane transplantation","volume":"42","author":"Barton K","year":"2001","unstructured":"Barton K, Budenz DL, Khaw PT, et al. Glaucoma filtration surgery using amniotic membrane transplantation. Invest Ophthalmol Vis Sci 2001; 42: 1762\u20131768.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000853"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijceo.2022.019"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000765"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2024.104734"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.10.032"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10235711"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01827-0"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199303000-00016"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318033b3d4"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.4103\/joco.joco_153_20"},{"key":"e_1_3_2_36_2","first-page":"100","article-title":"Intraoperative application of topical mitomycin C 0.05% for pterygium surgery","volume":"96","author":"Rodriguez JA","year":"2004","unstructured":"Rodriguez JA, Ferrari C, Hern\u00e1ndez GA. Intraoperative application of topical mitomycin C 0.05% for pterygium surgery. Bol Asoc Med P R 2004; 96: 100\u2013102.","journal-title":"Bol Asoc Med P R"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000141237.71837.d8"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4103\/jrpp.JRPP_19_127"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.3.350"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims-21-1166"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94909-8"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-01233-y"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-021-05321-x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-025-01627-y"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.11.003"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721261462633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721261462633","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721261462633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T13:57:54Z","timestamp":1782655074000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721261462633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":44,"alternative-id":["10.1177\/11206721261462633"],"URL":"https:\/\/doi.org\/10.1177\/11206721261462633","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"article-number":"11206721261462633"}}