{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:07:40Z","timestamp":1777579660336,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:p>\n                    S 872419 A, a specific receptor antagonist of peptide leukotrienes, was tested in the early-phase treatment of chemically burned eye (0.25 mol\/l sodium hydroxide) of the rabbit. The drug was topically applied 5 times a day in a 1% solution, controls were the untreated opposite eye. Gross and microscopic investigations indicated that S 872419 A inhibits the inflammatory response of the chemically burned anterior eye segment. The parameters of healing considered (epithelial regeneration, corneal clouding and swelling, infiltration with polymorphonuclear leukocytes) suggest inhibition of lipoxygenase-mediated reactions in the tissue. PGF\n                    <jats:sub>2alpha<\/jats:sub>\n                    levels were the same in aqueous humour of treated and untreated eyes. Further experiments with S 872419 A and other nonsteroidal drugs should improve the anti-inflammatory therapy of the chemically burned eye.\n                  <\/jats:p>","DOI":"10.1177\/112067219100100306","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T11:13:45Z","timestamp":1523877225000},"page":"137-141","source":"Crossref","is-referenced-by-count":10,"title":["Leukotriene Antagonist S 872419 A for Early-Phase Treatment of Chemical Burn in the Rabbit Eye"],"prefix":"10.1177","volume":"1","author":[{"given":"H.G.","family":"Struck","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Halle-Wittenberg - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Geiser","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Halle-Wittenberg - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.U.","family":"Block","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Martin Luther University, Halle-Wittenberg - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.","family":"Mest","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Martin Luther University, Halle-Wittenberg - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tost","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Halle-Wittenberg - Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,7,1]]},"reference":[{"key":"bibr1-112067219100100306","first-page":"190","volume":"47","author":"Anagnostopulos C.","year":"1988","journal-title":"Biomed Biochim Acta"},{"key":"bibr2-112067219100100306","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1987.3.357"},{"issue":"2","key":"bibr3-112067219100100306","first-page":"1246","volume":"39","author":"Bonne C.","year":"1989","journal-title":"Arzneim Forsch\/Drug Res"},{"key":"bibr4-112067219100100306","first-page":"41","volume":"5","author":"Chan C-C","year":"1990","journal-title":"Basel: Karger"},{"key":"bibr5-112067219100100306","first-page":"44","volume":"32","author":"Fujiwara H.","year":"1988","journal-title":"Jpn J Ophthalmol"},{"key":"bibr6-112067219100100306","doi-asserted-by":"publisher","DOI":"10.1007\/BF00143085"},{"key":"bibr7-112067219100100306","doi-asserted-by":"publisher","DOI":"10.1007\/BF02133874"},{"key":"bibr8-112067219100100306","first-page":"215","volume":"62","author":"Stjernschantz J.","year":"1984","journal-title":"Medical Biology"},{"key":"bibr9-112067219100100306","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1050276"},{"key":"bibr10-112067219100100306","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1046083"},{"key":"bibr11-112067219100100306","first-page":"110","volume":"5","author":"Verbeij N.L.J.","year":"1990","journal-title":"New Trends Lipid Mediators Res Basel: Karger"},{"key":"bibr12-112067219100100306","first-page":"481","volume":"26","author":"Woodward D.F.","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067219100100306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067219100100306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:38:09Z","timestamp":1777405089000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067219100100306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1177\/112067219100100306"],"URL":"https:\/\/doi.org\/10.1177\/112067219100100306","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}