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These manifestations mimicked the clinical picture of migraine and were associated with worsening of previous moderate Raynaud's syndrome and diffuse paraventricular lesions of the white matter seen in cerebral MRI. Bilateral posterior cerebral transient ischemic episodes rather than an anterior visual pathway lesion were thought to be responsible for the clinical symptoms though the exact role of interferon in these vasospastic-like disorders remains speculative. Their possible relationship with increased cryoglobulinemia is uncertain. We suggest that Raynaud's phenomenon may have a predisposing role for these manifestations.<\/jats:p>","DOI":"10.1177\/112067219500500413","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T11:15:33Z","timestamp":1523877333000},"page":"271-274","source":"Crossref","is-referenced-by-count":11,"title":["Bilateral Transient Visual Obscurations with Headaches during Alpha-II Interferon Therapy: A Case Report"],"prefix":"10.1177","volume":"5","author":[{"given":"M.","family":"Detry-Morel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, St. Luc University Hospital, UCL, Brussels - Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boschi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, St. Luc University Hospital, UCL, Brussels - Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gehenot","sequence":"additional","affiliation":[{"name":"Internal Medicine, St. Luc University Hospital, UCL, Brussels - Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Geubel","sequence":"additional","affiliation":[{"name":"Internal Medicine, St. Luc University Hospital, UCL, Brussels - Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1995,10,1]]},"reference":[{"key":"bibr1-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12874776"},{"key":"bibr2-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1126\/science.6154315"},{"key":"bibr3-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911303212204"},{"key":"bibr4-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31349-2"},{"key":"bibr5-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090030068041"},{"issue":"8","key":"bibr6-112067219500500413","first-page":"576","volume":"142","author":"Mansat-Krzyzzanowska E.","year":"1991","journal-title":"Ann Med Interne, Paris"},{"key":"bibr7-112067219500500413","first-page":"111","volume":"90","author":"Bauherz G.","year":"1990","journal-title":"Acta Neurol Belg"},{"key":"bibr8-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199003000-00035"},{"key":"bibr9-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411083111919"},{"key":"bibr10-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90405-0"},{"key":"bibr11-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1984.tb00801.x"},{"key":"bibr12-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90031-0"},{"key":"bibr13-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1983.63"},{"key":"bibr14-112067219500500413","first-page":"958","volume":"67","author":"Mattson K.","year":"1983","journal-title":"Cancer Treatment Reports"},{"key":"bibr15-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211193272104"},{"key":"bibr16-112067219500500413","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341221"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067219500500413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067219500500413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:41:53Z","timestamp":1777405313000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067219500500413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1177\/112067219500500413"],"URL":"https:\/\/doi.org\/10.1177\/112067219500500413","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}