{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:09:05Z","timestamp":1792188545731,"version":"4.4.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:p>This prospective, randomized clinical trial assessed the effects of mitomycin C and cyclosporin A used as antimetabolites in trabeculectomy on the post-operative IOP and success rate. Eighty-six consecutive patients were randomly allocated to three treatment groups. There were 30 patients in the mitomycin C group, 28 in the cyclosporin A group and 28 in the control group. The follow-up periods were different for the three groups and ranged from 6 to 30 months. The treatment groups consisted of primary open-angle glaucoma, closed-angle glaucoma, various secondary glaucomas and prior failed trabeculectomy. There were no significant differences pre-operatively with respect to IOP and number of medications used (p&gt;0.05). Postoperative IOP was considered to be successfully reduced when it was reduced by more than 25% from baseline or when it was lower than 20 mmHg. According to these criteria, IOP was under control in 90% of the mitomycin C treated eyes, 85.7% of cyclosporin A treated eyes and 71.4% of the control eyes. Postoperatively there was a significant decrease in IOP (p&lt;0.01) and in the number of medications needed to control IOP (p&lt;0.01) in the mitomycin C and cyclosporin A groups. Post-operative IOP and number of medications in the mitomycin C and cyclosporin A groups were similar. Complications encountered in the three groups were similar. There were no serious complications like hypotonus maculopathy. Our study highlights the utility of mitomycin C as an adjunct in glaucoma filtering surgery and indicates that cyclosporin A may also be used as an antimetabolite.<\/jats:p>","DOI":"10.1177\/112067219600600410","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T11:16:06Z","timestamp":1523877366000},"page":"398-401","source":"Crossref","is-referenced-by-count":20,"title":["A Comparative Clinical Trial of Mitomycin C and Cyclosporin a in Trabeculectomy"],"prefix":"10.1177","volume":"6","author":[{"given":"E.","family":"Tura\u00e7li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, University of Ankara, Ankara - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, University of Ankara, Ankara - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Aktan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, University of Ankara, Ankara - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tamer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, University of Ankara, Ankara - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"bibr1-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1007\/BF02334165"},{"key":"bibr2-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(89)90853-2"},{"key":"bibr3-112067219600600410","first-page":"172","volume":"9","author":"Chen C.W.","year":"1983","journal-title":"Trans Asia Pacific Acad Ophthalmol"},{"key":"bibr4-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1990.6.175"},{"key":"bibr5-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32293-0"},{"key":"bibr6-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080120077030"},{"key":"bibr7-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(68)91288-9"},{"key":"bibr8-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.1993.12088576"},{"key":"bibr9-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(81)90153-X"},{"key":"bibr10-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070110139038"},{"key":"bibr11-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1987.90"},{"key":"bibr12-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070010071030"},{"key":"bibr13-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1994.44"},{"key":"bibr14-112067219600600410","author":"Tura\u00e7li E.","year":"1994","journal-title":"Topical cyclosporin in trabeculectomy: a possible new antimetabolite."},{"key":"bibr15-112067219600600410","first-page":"249","volume":"1","author":"Tura\u00e7li E.","year":"1994","journal-title":"28th Turkish National Ophthalmology Congress Bulletin"},{"key":"bibr16-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1007\/BF00156420"},{"key":"bibr17-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)31049-4"},{"key":"bibr18-112067219600600410","author":"Tura\u00e7li E.","year":"1994","journal-title":"Trabeculectomy with mitomycin C: an electron microscopic and clinical study."},{"key":"bibr19-112067219600600410","first-page":"1211","volume":"2","author":"Tura\u00e7li E.","year":"1993","journal-title":"27th Turkish National Ophthalmology Congress Bulletin"},{"key":"bibr20-112067219600600410","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31427-2"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067219600600410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067219600600410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:42:21Z","timestamp":1777405341000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067219600600410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["10.1177\/112067219600600410"],"URL":"https:\/\/doi.org\/10.1177\/112067219600600410","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10]]}}}