{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:21:34Z","timestamp":1777580494747,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of a newly developed ophthalmic solution containing carteolol 2% and pilocarpine (2% (CBS341A) with a timolol 0.5% and pilocarpine 2% fixed combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods.<\/jats:title>\n                    <jats:p>A randomized, double-masked, multicenter study was conducted in 209 patients with primary open-angle glaucoma or ocular hypertension, whose intraocular pressure (IOP) was higher than 21 mm Hg on bet-blocker twice a day alone. The test medications were administered twice daily for 4 months. IOP was measured at 9 and 11 a.m. at the beginning of the study (with beta-blocker alone) and after one and four months of treatment. Adverse effects were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both combinations caused a similar, statistically significant decrease in IOP. At four months, in the CBS341A group a 2.4 mm Hg (9%) reduction in IOP was achieved at 9 a.m. and 4.1 mm Hg (17.3%) at 11 a.m. compared with respectively 3 mm Hg (11%) and 4.5 mm Hg (19.5%) in the timolol-pilocarpine group. No statistical difference was observed between the two groups in safety and efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The carteolol-pilocarpine combination appears as safe and as effective as the timolol-pilocarpine combination in the medical treatment of primary open-angle glaucoma or ocular hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067219700700408","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T11:10:23Z","timestamp":1523877023000},"page":"351-356","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Two Fixed Beta-Blocker-Pilocarpine Combinations"],"prefix":"10.1177","volume":"7","author":[{"name":"The Carteolol-Pilocarpine Study Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Bron","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, CHU H\u00f4pital General, Dijon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P.","family":"Garcher","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, CHU H\u00f4pital General, Dijon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sirbat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, CHU H\u00f4pital General, Strasbourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Allaire","sequence":"additional","affiliation":[{"name":"Laboratoire Chauvin, Montpellier - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Lablache-Combier","sequence":"additional","affiliation":[{"name":"Laboratoire Chauvin, Montpellier - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J. M.","family":"Trinquand","sequence":"additional","affiliation":[{"name":"Laboratoire Chauvin, Montpellier - France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,10,1]]},"reference":[{"key":"bibr1-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(87)90116-0"},{"key":"bibr2-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199204000-00003"},{"key":"bibr3-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.66.7.464"},{"key":"bibr4-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90939-6"},{"key":"bibr5-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1990.tb01931.x"},{"key":"bibr6-112067219700700408","first-page":"140","volume":"14","author":"Loefors K.T.","year":"1992","journal-title":"Glaucoma"},{"key":"bibr7-112067219700700408","first-page":"79","volume":"2","author":"Maclure G.R.","year":"1987","journal-title":"New Trend Ophthalmol"},{"key":"bibr8-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.73.10.827"},{"key":"bibr9-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(87)90168-1"},{"key":"bibr10-112067219700700408","first-page":"149","volume":"14","author":"Bucci M.G.","year":"1992","journal-title":"Glaucoma"},{"key":"bibr11-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1987.tb07048.x"},{"key":"bibr12-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080240065032"},{"key":"bibr13-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(89)90489-3"},{"key":"bibr14-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199508000-00004"},{"key":"bibr15-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1983.159"},{"key":"bibr16-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199400340-00013"},{"key":"bibr17-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199400340-00009"},{"key":"bibr18-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(88)90178-X"},{"key":"bibr19-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1007\/BF00167880"},{"key":"bibr20-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.52.8.607"},{"key":"bibr21-112067219700700408","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199404000-00014"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067219700700408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067219700700408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:42:42Z","timestamp":1777405362000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067219700700408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1177\/112067219700700408"],"URL":"https:\/\/doi.org\/10.1177\/112067219700700408","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}