{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:22:19Z","timestamp":1777580539384,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This work describes the snake-like chromatin cells in the conjunctiva of patients with keratoconjunctivitis sicca (KCS), assessing the relationship between tear function parameters and the severity of the disease, and searching for any differential pattern that could lead to early and diagnosis help clarify the etiology of KCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The conjunctiva of 366 eyes from 187 patients with KCS, and 30 eyes from 15 controls, were classified according to the results of the Schirmer I test, break-up time, rose Bengal staining, osmolarity, ferning tests and electrophoresis; they were then studied by impression cytology and electron microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Snake-like chromatin cells, other nuclear changes, and a decreased number of goblet cells were found by impression cytology in different areas of the KCS conjunctiva. The presence of snake-like chromatin was significantly correlated with the severity of the disease. No nuclear changes were found in the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We assume these findings can be attributed to a natural regeneration of conjunctival cells and to resistance to a pathological reaction to KCS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067219800800403","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T12:15:49Z","timestamp":1520943349000},"page":"217-223","source":"Crossref","is-referenced-by-count":3,"title":["The Association of Conjunctival Snake-Like Chromatin with Keratoconjunctivitis Sicca"],"prefix":"10.1177","volume":"8","author":[{"given":"L.","family":"Rivas","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Dacryology Laboratory. Ram\u00f3n y Cajal Hospital, Madrid - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Oroza","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dacryology Laboratory. Ram\u00f3n y Cajal Hospital, Madrid - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.I.","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dacryology Laboratory. Ram\u00f3n y Cajal Hospital, Madrid - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhujiang Hospital. Guangzhou - P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Department of Ophthalmololy, University of Tanta - Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Murube","sequence":"additional","affiliation":[{"name":"University of Alcal\u00e1 de Henares, Madrid - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,10,1]]},"reference":[{"key":"bibr1-112067219800800403","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1980.tb06700.x"},{"key":"bibr2-112067219800800403","first-page":"711","volume":"35","author":"Knop E.","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr3-112067219800800403","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-198702710-00008"},{"key":"bibr4-112067219800800403","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-198801000-00012"},{"key":"bibr5-112067219800800403","first-page":"157","volume-title":"The preocular tear film in health, disease and contact lens wear.","author":"Prause J.U.","year":"1985"},{"key":"bibr6-112067219800800403","first-page":"125","volume":"1","author":"Knop E.","year":"1992","journal-title":"German J Ophthalmol"},{"key":"bibr7-112067219800800403","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165940"},{"key":"bibr8-112067219800800403","first-page":"163","volume":"36","author":"Kobayaski T.K.","year":"1992","journal-title":"Acta Cytological"},{"key":"bibr9-112067219800800403","first-page":"711","volume":"35","author":"Knop E.","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr10-112067219800800403","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1995.tb00009.x"},{"key":"bibr11-112067219800800403","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.2.116"},{"key":"bibr12-112067219800800403","unstructured":"TsengS.C.G. 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New York: International Ophthalmology Clinics 1994; 37\u201356.","DOI":"10.1097\/00004397-199403410-00006"},{"key":"bibr14-112067219800800403","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.7.473"},{"key":"bibr15-112067219800800403","first-page":"145","volume":"7","author":"Murube del Castillo J.","year":"1989","journal-title":"Clin Exp Rheumath"},{"key":"bibr16-112067219800800403","first-page":"45","volume-title":"Guide pratique des examens de laboratoire en ophtalmologie.","author":"Liotet S.","year":"1988"},{"key":"bibr17-112067219800800403","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(88)90587-9"},{"key":"bibr18-112067219800800403","first-page":"187","volume":"62","author":"Roberts D.K.","year":"1991","journal-title":"J Amer Opto Assoc"},{"key":"bibr19-112067219800800403","first-page":"35","volume-title":"El Ojo Seco","volume":"2","author":"Lemp M.A.","year":"1994"},{"key":"bibr20-112067219800800403","first-page":"306","volume":"4","author":"Rivas L.","year":"1995","journal-title":"German J Ophthalmol"},{"key":"bibr21-112067219800800403","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74397-1"},{"key":"bibr22-112067219800800403","first-page":"1879","volume":"30","author":"Ohashi Y.","year":"1989","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067219800800403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067219800800403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:42:57Z","timestamp":1777405377000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067219800800403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1177\/112067219800800403"],"URL":"https:\/\/doi.org\/10.1177\/112067219800800403","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}