{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:22:13Z","timestamp":1789820533142,"version":"4.0.1"},"reference-count":16,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIP International"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Hip fractures represent an enormous challenge for our health care system. The aim of this randomised controlled trial was to assess both efficacy and safety of a novel device called Prevention Nail System (PNS) and developed for the surgical prevention of a contralateral femoral neck fracture (FNF) in elderly osteoporotic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Primary outcome was to evaluate, in patients suffering from osteoporotic FNF, the effectiveness of PNS in reducing the incidence of a contralateral hip fracture. Secondary outcome was to evaluate the safety of this device therefore intra- and postoperative complications were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>72 patients, with an age \u2a7e65 years old, were enrolled (38 study group (group A) and 34 control group (group B). 3 and 5 contralateral FNF were recorded respectively in group A and B. An interim analysis showed a non-effectiveness of the device therefore enrollment was suspended.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>In all group A failures a difficult positioning of the PNS was recorded: surgical techniques errors may have affected the result. Nevertheless, it is improbable to hypothesise that, without substantial modifications to the PNS design, this could significantly reduce the incidence of FNF. Considering that current pharmacological approach can achieve, at best, a marginal reduction in FNF especially in patients at high risk, complementary approaches to provide immediate prevention of hip fractures may need to be developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Protocol:<\/jats:title>\n                    <jats:p>N\u00b0 263. 03 June 2008.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120700018813207","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T04:44:40Z","timestamp":1545972280000},"page":"78-83","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Surgical prevention of femoral neck fractures in elderly osteoporotic patients: a randomised controlled study on the prevention nail system device"],"prefix":"10.1177","volume":"28","author":[{"given":"Sandro","family":"Giannini","sequence":"first","affiliation":[{"name":"I.R.C.C.S. \u2013 Istituto Ortopedico Rizzoli, Bologna, Italy"},{"name":"University of Bolgna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Chiarello","sequence":"additional","affiliation":[{"name":"Orthopaedics and Traumatology, \u201cOspedale dell\u2019Angelo,\u201d Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Mazzotti","sequence":"additional","affiliation":[{"name":"I.R.C.C.S. \u2013 Istituto Ortopedico Rizzoli, Bologna, Italy"},{"name":"University of Bolgna, Italy"},{"name":"1st Orthoapedic and Trauma Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiseppe","family":"Tedesco","sequence":"additional","affiliation":[{"name":"I.R.C.C.S. \u2013 Istituto Ortopedico Rizzoli, Bologna, Italy"},{"name":"Unit of Oncologic and Degenerative Spine Surgery, I.R.C.C.S. \u2013 Istituto Ortopedico Rizzoli, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Faldini","sequence":"additional","affiliation":[{"name":"I.R.C.C.S. \u2013 Istituto Ortopedico Rizzoli, Bologna, Italy"},{"name":"University of Bolgna, Italy"},{"name":"1st Orthoapedic and Trauma Clinic, Rizzoli Orthopaedic Institute, Bologna, 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