{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:49:02Z","timestamp":1783482542976,"version":"3.55.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIP International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the predictive value of pre-fracture medication usage on 30-day mortality following a hip fracture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Information on age, sex, fracture type, time of death and Charlson co-morbidity index (CCI) was collected from the Danish National Patient Registry on all patients above 60\u2009years, sustaining a hip fracture during the period January 1995 to December 2013. Information on drug usage was obtained from the Danish National Prescription Database. Hazard ratios were calculated with 30-day mortality as the outcome. A univariate and 3 multivariate analyses were conducted with increasing adjustments, starting with age, sex and fracture type, adding co-morbidity and dose in the latter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>141,201 patients were included and a total of 12 drugs\/drug groups were identified for analysis. Increased mortality was evident in all analyses for antiarrhythmics, beta blockers, proton pump inhibitors, loop diuretics, opioids, acetaminophen and for psycholeptics. For ACE-inhibitors, increased mortality was found in all analyses, except after adjustment for co-morbidity and dose. For thiazide diuretics, a significantly reduced mortality was evident in all but the univariate analyses while NSAIDs and statins were associated with a significantly reduced mortality in all analyses. For calcium channel blockers, an insignificant decrease was found after adjustment for dose. Further analysis showed a dose-response relationship for all drugs except ACE-inhibitors and calcium channel blockers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study shows a correlation between pre-fracture usage of certain drugs and 30\u2009day mortality after a hip fracture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120700019832603","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T06:31:39Z","timestamp":1551421899000},"page":"101-106","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Pre-fracture medication use as a predictor of 30-day mortality in hip fracture patients: an analysis of 141,201 patients"],"prefix":"10.1177","volume":"30","author":[{"given":"Christopher","family":"Jantzen","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Abrahamsen","sequence":"additional","affiliation":[{"name":"Odense Patient Data Explorative Network, Institute of Clinical Research, University of Southern Denmark and Department of Medicine, Holb\u00e6k Hospital, Holb\u00e6k, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Van Der Mark","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benn R","family":"Duus","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Howland","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Boston University School of Medicine, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes B","family":"Lauritzen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik L","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, 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