{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:44:32Z","timestamp":1778262272109,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIP International"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Hip fractures represent 1 of the most common injuries in older adults. They are associated with increased perioperative morbidity and mortality. Additionally, current research suggests that SARS-COV-2 infection may worsen the prognosis of the hip fracture patients who undergo hip fixation. The aims of the present study were: (1) to determine the rate of specific adverse events including VTE (venous thromboembolism) and major adverse cardiovascular events (MACEs) in patients with hip fracture and concomitant SARS-CoV-2 infection undergoing surgery; and (2) to examine if the aforementioned population is at increased risk for VTE and MACEs, when compared to SARS-CoV-2 free patients with hip fracture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PubMed, EMBASE, Cochrane, Web of Science, Google scholar and medRxiv were searched from March 2020 to January 2021 for English language studies with patients suffering from hip fractures and SARS-COV-2 -CoV-2. 2 researchers were involved in the data extraction and the quality assessment of the studies respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The literature search yielded a total of 1256 articles of which 14 were included in the systematic review and 7 in the meta-analysis respectively. The estimated pooled rate for VTE and MACE were 4.3% and 6.3% respectively. Patients with hip fracture and concomitant SARS-CoV-2 infection who undergo surgery are at increased risk for VTE, when compared to SARS-CoV-2 free patients (odds ratio 2.8 [95% CI, 1.1\u20137.1]). These patients are also at increased risk for MACE postoperatively as indicated by the odds ratio 2.4 (95% CI, 1.0\u20135.8). The quality of the studies was moderate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although there is a lack of high-quality data it seems that patients with hip fractures and concomitant SARS-CoV-2 infection are facing a 2.8 and 2.4 times increased risk for VTE and MACE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11207000221132489","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T02:11:58Z","timestamp":1666750318000},"page":"1122-1132","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Venous thromboembolism and major adverse cardiovascular events in patients with hip fractures suffering from SARS-CoV-2 infection: a systematic review"],"prefix":"10.1177","volume":"33","author":[{"given":"Antonios A","family":"Koutalos","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery and Musculoskeletal Trauma, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-9342","authenticated-orcid":false,"given":"Maria P","family":"Ntalouka","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9008-0005","authenticated-orcid":false,"given":"Fragkiskos A","family":"Angelis","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Musculoskeletal Trauma, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hantes","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Musculoskeletal Trauma, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Arnaoutoglou","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"bibr1-11207000221132489","doi-asserted-by":"publisher","DOI":"10.1007\/s43465-021-00386-6"},{"key":"bibr2-11207000221132489","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3616-5"},{"key":"bibr3-11207000221132489","doi-asserted-by":"publisher","DOI":"10.1302\/2633-1462.25.BJO-2020-0183.R1"},{"key":"bibr4-11207000221132489","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15458"},{"key":"bibr5-11207000221132489","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znab101"},{"key":"bibr6-11207000221132489","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins JP","year":"2011"},{"key":"bibr7-11207000221132489","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"bibr8-11207000221132489","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"bibr9-11207000221132489","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60903-8"},{"key":"bibr10-11207000221132489","volume":"355","author":"Sterne JA","year":"2016","journal-title":"BMJ"},{"key":"bibr11-11207000221132489","unstructured":"National Heart Lung and Blood Institute (NHI\/NHLBI). 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