{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:13:28Z","timestamp":1777677208089,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIP International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>10 years after changing our institution\u2019s total hip arthroplasty (THA) preoperative antibiotic prophylactic protocol by adding gram-negative (GN) coverage, this study aimed to assess the impact of adding GN specific coverage (GNSC) prior to THA on periprosthetic joint infection (PJI) rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective case-control study of 14,598 patients who underwent primary, elective THA between July 2012 and January 2022, with minimum 1-year follow-up. All patients were under perioperative antibiotic protocol that included GNSC with either weight-based gentamicin or aztreonam (+GNSC) and were compared to a historical control group of patients for which the antibiotic prophylactic protocol did not include GNSC (-GNSC). PJI and nephrotoxicity rates, as well as the severity of nephrotoxicity according to the RIFLE criteria, were compared between the study populations and 4122 controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Proportions of GN-related PJIs among culture-positive (13.70 vs. 26.53%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.076) and all PJIs (10.64 vs. 26.53%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.014) were lower for +GNSC patients, while the proportion of PJIs caused by a gram-positive bacteria were similar between groups (87.67 vs. 83.67%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.532). While the +GNSC group have significantly higher rates of nephrotoxicity (2.87 vs. 1.78%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003), the rates of kidney injury (0.39 vs. 0.39%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.998) and kidney failure (0.17 vs. 0.16%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.567), which are the two more severe forms of nephrotoxicity, were comparable between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The addition of gentamicin or aztreonam prior to THA reduces the incidence of GN-related PJIs. Increased nephrotoxicity rates were limited to the mildest form, usually associated with reversibility and favourable outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11207000251364214","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T09:42:38Z","timestamp":1755510158000},"page":"18-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The sustained benefits of gram-negative antimicrobial prophylaxis in total hip arthroplasty: a 10-year retrospective analysis"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-9120","authenticated-orcid":false,"given":"Itay","family":"Ashkenazi","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, NYU Langone Health, New York, NY, USA"},{"name":"Division of Orthopaedic Surgery, Tel-Aviv Sourasky Medical Centre, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weston","family":"Buehring","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Arshi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay K","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Schwarzkopf","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-020-03731-w"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2018.05.042"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2015.1035173"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00990"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.210.2000188"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-017-5302-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.411.2000432"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed5040186"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s42836-022-00113-y"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.09.051"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1302\/2633-1462.31.BJO-2021-0051.R1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.101B6.BJJ-2018-1407.R1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/605593"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.106884"},{"key":"e_1_3_2_16_2","article-title":"Orthopedic surgical site infections: analysis of causative bacteria and implications for antibiotic stewardship","volume":"43","author":"Norton TD","year":"2014","unstructured":"Norton TD, Skeete F, Dubrovskaya Y, et al. 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