{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:28:12Z","timestamp":1792794492159,"version":"4.5.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIP International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Periprosthetic joint infection (PJI) is a devastating complication of total hip arthroplasty (THA) that has major clinical and financial implications. Despite CDCR being the accepted gold standard for chronic PJI, serious complications, such as extensive bone loss and protracted rehabilitation, have led to the investigation of PTCR as an alternative treatment strategy for chronic PJI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>According to the PICOS framework, a systematic review and meta-analysis were performed to assess the clinical efficacy of partial 2-stage exchange in chronic PJI with a stable femoral component. There were no time or language limits during the search for relevant articles in PubMed, Embase, Scopus, and Cochrane Library databases. Data extraction and quality assessment were performed according to the MINORS criteria by 2 independent reviewers. Statistical analysis, including heterogeneity and sensitivity analyses, was performed using R Studio software with the appropriate meta-analytical packages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>13 studies, including 239 patients, were analysed. When the data were pooled, MDCT showed an 88% rate of complete eradication with homogeneity (I\u00b2\u2009=\u20090%). Secondary traits included 12% re-operations, 8% deaths, and 1% fractures. Infectious and systemic complications were observed in 13% and 3% of patients, respectively. Implant stability was present in 89% of cases, with significant functional improvement, with a mean Harris Hip Score of 37.77 at the final follow-up. Treatment failure, defined as infection recurrence or the need for chronic antibiotic suppression, was observed in 14% of cases, and sensitivity analysis excluding zero-event studies showed a 17% failure rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Partial 2-stage exchange results in favorable eradication of infection, may reduce bone stock loss, and optimises functional outcomes. However, concerns remain regarding its efficacy against resistant strains and proper patient selection criteria. Well-designed comparative studies with longer follow-up periods are needed to establish treatment algorithms and confirm long-term clinical results.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>PROSPERO<\/jats:bold>\n                      registration number CRD42024599183.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11207000251406507","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:50:18Z","timestamp":1773240618000},"page":"406-422","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Partial 2-stage exchange for chronic periprosthetic joint infection after total hip arthroplasty: a comprehensive meta-analysis"],"prefix":"10.1177","volume":"36","author":[{"given":"Jos\u00e9 Mar\u00eda","family":"Lamo-Espinosa","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, IMED Col\u00f3n, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5166-198X","authenticated-orcid":false,"given":"Gonzalo","family":"Mariscal","sequence":"additional","affiliation":[{"name":"La Fe University and Polytechnic Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Soler","sequence":"additional","affiliation":[{"name":"Soler Trauma Clinic, Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"G\u00f3mez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Tumor and Hip Surgery Unit, Hospital 9 de Octubre, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Sevil","sequence":"additional","affiliation":[{"name":"Tumor and Hip Surgery Unit, Hospital 9 de Octubre, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4479-2316","authenticated-orcid":false,"given":"Ibrahim","family":"Khalil","sequence":"additional","affiliation":[{"name":"Faculty of medicine, Alexandria University Faculty of Medicine, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed","family":"Balbaa","sequence":"additional","affiliation":[{"name":"Faculty of medicine, Alexandria University Faculty of Medicine, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Corb\u00ed","sequence":"additional","affiliation":[{"name":"Tumor and Hip Surgery Unit, Hospital 9 de Octubre, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"San-Juli\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Catholic University of Valencia San Vicente M\u00e1rtir Language Institute, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00111-13"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60457-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.01.021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.106884"},{"key":"e_1_3_2_6_2","first-page":"1746","article-title":"The impact of infection after total hip arthroplasty on hospital and surgeon resource utilization","volume":"87","author":"Bozic KJ","year":"2005","unstructured":"Bozic KJ, Ries MD. The impact of infection after total hip arthroplasty on hospital and surgeon resource utilization. J Bone Joint Surg Am 2005; 87: 1746\u20131751.","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis966"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040181"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.95B11.32906"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200409000-00018"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3168-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2595-x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/112070001002000305"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2013.795830"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/112070000901900319"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-016-4987-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2022.02.060"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.08.002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.5371\/hp.2016.28.1.1"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B6.15411"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.96B11.34360"},{"key":"e_1_3_2_24_2","first-page":"1746","article-title":"The impact of infection after total hip arthroplasty on hospital and surgeon resource utilization","volume":"87","author":"Bozic KJ","year":"2005","unstructured":"Bozic KJ, Ries MD. The impact of infection after total hip arthroplasty on hospital and surgeon resource utilization. J Bone Joint Surg Am 2005; 87: 1746\u20131751.","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200210000-00003"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-016-3291-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-016-4936-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000130757.53559.BF"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13010137"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-019-04473-0"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2015.09.006"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-017-3505-3"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh032"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.332-335.2006"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.07.001"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/1120700019855627"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04550-9"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-2030-8"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200011000-00003"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B8.17445"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199610000-00016"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.12.005"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00356"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B3.28256"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2024.05.086"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11061657"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239981"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.90B12.20742"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-024-08199-y"}],"container-title":["HIP International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11207000251406507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11207000251406507","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11207000251406507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:43:40Z","timestamp":1779792220000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11207000251406507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/11207000251406507"],"URL":"https:\/\/doi.org\/10.1177\/11207000251406507","relation":{},"ISSN":["1120-7000","1724-6067"],"issn-type":[{"value":"1120-7000","type":"print"},{"value":"1724-6067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]}}}