{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T19:05:22Z","timestamp":1789326322895,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIP International"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed among total hip arthroplasty (THA) candidates, yet their perioperative impact remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using TriNetX, we identified adults undergoing primary THA (2003\u20132023) with preoperative GLP-1 RA exposure (\u2a7e3 prescriptions within 1\u2009year of surgery) versus controls. 1:1 propensity score matching for demographics, comorbidities, and baseline labs yielded 1262 patients per cohort. Outcomes included 90-day medical complications and mechanical complications (PJI, dislocation, aseptic loosening, periprosthetic fracture, all-cause revision) at 1, 2, and 5\u2009years, reported in accordance with the STROBE guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At 90\u2009days, the GLP-1 RA cohort demonstrated significantly lower risks of DVT (1.6% vs. 3.0%; RR 0.53, 95% CI, 0.31\u20130.89;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.014) and hospital readmission (1.1% vs. 2.8%; RR 0.40, 95% CI, 0.22\u20130.71;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001). No significant differences were found in other 90-day outcomes or in mechanical complications, including all-cause revision (94.6% vs. 95.5% survival;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.674) and PJI (94.7% vs. 94.4%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.465) at 5\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Consistent preoperative GLP-1 RA use is associated with reduced 90-day DVT and readmission following primary THA without increased risk of other complications or mechanical outcomes at 5\u2009years. As DVT was the only significant thromboembolic endpoint, prospective investigation is needed before attributing a thromboprophylactic effect to these agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11207000261476202","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:55:45Z","timestamp":1789124145000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative GLP-1 receptor agonist use and outcomes after total hip arthroplasty: a matched cohort study"],"prefix":"10.1177","author":[{"given":"Abdel R","family":"Diab","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-6163","authenticated-orcid":false,"given":"Tony H W","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Diab","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-6746","authenticated-orcid":false,"given":"Michael M","family":"Kheir","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_3_2_2_2","article-title":"Projections and epidemiology of primary hip and knee arthroplasty in Medicare patients to 2040-2060","volume":"8","author":"Shichman I","year":"2023","unstructured":"Shichman I, Roof M, Askew N, et al. Projections and epidemiology of primary hip and knee arthroplasty in Medicare patients to 2040-2060. JB JS Open Access 2023; 8: e22.00112.","journal-title":"JB JS Open Access"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.10.005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17138"},{"key":"e_1_3_2_5_2","article-title":"What is the impact of body mass index cutoffs on total hip arthroplasty complications?","volume":"37","author":"DeMik DE","year":"2022","unstructured":"DeMik DE, Kohler JG, Carender CN, et al. What is the impact of body mass index cutoffs on total hip arthroplasty complications? J Arthroplasty 2022; 37: 1320\u20131325.e1.","journal-title":"J Arthroplasty"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25175"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.5371\/hp.2022.34.3.161"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-24-00154"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00960"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-024-05381-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.09.046"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2024.02.051"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.102B6.BJJ-2019-1644.R1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.08.019"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s42836-024-00237-3"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0016-2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-24-01590"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S008"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2024.12.008"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2024.05.079"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2023.12.002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/dbi16-0014"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2025015871"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2025.09.054"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/10225536251391959"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2024.07.045"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2024.10.099"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.sart.2024.10.001"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106320"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-024-00647-3"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-024-02415-w"}],"container-title":["HIP International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11207000261476202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11207000261476202","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11207000261476202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:50:34Z","timestamp":1789325434000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11207000261476202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":32,"alternative-id":["10.1177\/11207000261476202"],"URL":"https:\/\/doi.org\/10.1177\/11207000261476202","relation":{},"ISSN":["1120-7000","1724-6067"],"issn-type":[{"value":"1120-7000","type":"print"},{"value":"1724-6067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"article-number":"11207000261476202"}}