{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:34:48Z","timestamp":1782488088579,"version":"3.54.5"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>The objective of this systematic review is to evaluate the safety ad feasibility of the totally implantable vascular access devices (TIVADs) flushed more than 4\u2009weeks. We searched the following electronic databases from the date their build-up to February 2020: PubMed, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL. The final selection resulted in 14 trials fulfilling the inclusion criteria and being included in our review. A pooled frequency of port-related late complications with longer flushing intervals (&gt;4\u2009weeks) was 8.0%, and the pooled frequency of occlusions, infections, and mechanical complications was 5.0%, 2.0%, and 3.0%, respectively. Then, we compared the frequency of port-related complications between standard and longer flushing intervals. There were no differences between the group\u2019s changes in the frequency of total late complications, occlusions, infections, and mechanical complications. This systematic review and meta-analysis demonstrates that longer flushing intervals for ports are safe. However, more prospective, power appropriated randomized trials are needed to explore the specific flushing time for ports.<\/jats:p>","DOI":"10.1177\/11297298211003003","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T02:26:14Z","timestamp":1616466374000},"page":"969-978","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Prolonged flushing and locking interval for totally implantable vascular access device: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-3340","authenticated-orcid":false,"given":"Zhao-yu","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-min","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-yun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"key":"bibr1-11297298211003003","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174164"},{"key":"bibr2-11297298211003003","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2208-1"},{"key":"bibr3-11297298211003003","doi-asserted-by":"publisher","DOI":"10.1177\/1129729819884482"},{"key":"bibr4-11297298211003003","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000361"},{"key":"bibr5-11297298211003003","first-page":"343","volume":"11","author":"Okazaki M","year":"2019","journal-title":"Mol Clin Oncol"},{"key":"bibr6-11297298211003003","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e31823312b1"},{"key":"bibr7-11297298211003003","doi-asserted-by":"publisher","DOI":"10.1080\/07357900500276923"},{"key":"bibr8-11297298211003003","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.04.435"},{"key":"bibr9-11297298211003003","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.28.15_suppl.e19635"},{"key":"bibr10-11297298211003003","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"bibr11-11297298211003003","doi-asserted-by":"crossref","unstructured":"Tufanaru C, Munn Z, Aromataris E, et al. 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