{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:20:48Z","timestamp":1778325648803,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"M.A. MedAlliance SA"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Aim of this pilot clinical study was to evaluate the safety and efficacy of the Selution Sustained Limus Release (SLR)\u2122 sirolimus-eluting balloon (SEB) for improving failing arterio-venous fistulas (AVF) patency in Asian haemodialysis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective single-centre, multi-investigator, non-consecutive, non-blinded single arm trial. Forty end-stage renal failure Asian patients with a dysfunctional AVF underwent SEB angioplasty between May and November 2020. All stenotic lesions were prepared with high pressure non-compliant balloon angioplasty prior to SEB angioplasty. Endpoints of interest included target lesion primary patency and circuit access patency and safety through 30\u2009days. All patients received dual antiplatelet therapy for 1\u2009month and were followed up with Duplex ultrasound at 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There was one subject dropout so final n\u2009=\u200939 patients (mean age 65.0\u2009\u00b1\u200911.9; males\u2009=\u200926 (66.7%)) and n\u2009=\u200943 target lesions treated. Main indication for intervention was dropping access flow (24\/39; 61.5%) and most common target lesion was in the juxta-anastomosis (24\/43; 54.5%). There was 100% technical and procedural success. There were no adverse events related to the SEB. Target lesion primary patency rates at 3 and 6\u2009months were 39\/41 (95.1%) and 28\/39 (71.8%) respectively. Access circuit patency rates at 3 and 6\u2009months were 35\/37 (94.6%) and 22\/35 (62.9%) respectively. There were 3 (7.7%) deaths all attributable to patients\u2019 underlying co-morbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Fistuloplasty using the novel Selution SLR\u2122 SEB for dysfunctional AVF circuits seems a safe and effective modality in Asian haemodialysis patients at 6\u2009months but larger randomised controlled studies are required now to determine its true efficacy against plain balloon angioplasty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11297298211067059","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T04:18:22Z","timestamp":1640837902000},"page":"1008-1017","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Endovascular salvage of failing arterio-venous fistulas utilising sirolimus eluting balloons: Six months results from the ISABELLA trial"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8524-7912","authenticated-orcid":false,"given":"Tjun Y","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Singapore General Hospital, Singapore"},{"name":"Duke NUS Graduate Medical School, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3057-5983","authenticated-orcid":false,"given":"Shereen XY","family":"Soon","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-0842","authenticated-orcid":false,"given":"Charyl JQ","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1491-2302","authenticated-orcid":false,"given":"Ru Yu","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suh Chien","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Vascular Interventional Radiology, Sengkang General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apoorva","family":"Gogna","sequence":"additional","affiliation":[{"name":"Department of Vascular Interventional Radiology, Sengkang General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-5585","authenticated-orcid":false,"given":"Chieh Suai","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze Tec","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"bibr1-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00117.x"},{"key":"bibr2-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.12.001"},{"key":"bibr3-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.09.004"},{"key":"bibr4-11297298211067059","first-page":"369687","volume":"2014","author":"Bountouris I","year":"2014","journal-title":"Int J Vasc Med"},{"key":"bibr5-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005050615"},{"key":"bibr6-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1159\/000343669"},{"key":"bibr7-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1583\/11-3690.1"},{"issue":"6","key":"bibr8-11297298211067059","first-page":"S3","volume":"5","author":"Horwitz SB","year":"1994","journal-title":"Ann Oncol"},{"key":"bibr9-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60657-2"},{"key":"bibr10-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.01.041"},{"key":"bibr11-11297298211067059","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000508"},{"key":"bibr12-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2019.08.035"},{"key":"bibr13-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.02.040"},{"key":"bibr14-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31820577df"},{"key":"bibr15-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.11.040"},{"key":"bibr16-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1177\/15266028211007457"},{"key":"bibr17-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2021.04.014"},{"key":"bibr18-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2020.11.010"},{"key":"bibr19-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1177\/11297298211020867"},{"issue":"1","key":"bibr20-11297298211067059","first-page":"S248","volume":"48","author":"Vascular Access Work Group","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"bibr21-11297298211067059","unstructured":"The R Foundation. RCT. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2018. https:\/\/www.R-project.org\/"},{"key":"bibr22-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241321"},{"key":"bibr23-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1177\/1129729819848609"},{"key":"bibr24-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206011"},{"key":"bibr25-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.08.031"},{"key":"bibr26-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.11.022"},{"key":"bibr27-11297298211067059","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.14231217"},{"key":"bibr28-11297298211067059","volume-title":"Conference proceedings","author":"Holden A"},{"key":"bibr29-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1914617"},{"key":"bibr30-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2019.01.012"},{"key":"bibr31-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011245"},{"key":"bibr32-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2019.11.015"},{"key":"bibr33-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1177\/1526602819872154"},{"key":"bibr34-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2014-000117"},{"key":"bibr35-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231463"},{"key":"bibr36-11297298211067059","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018170806"}],"container-title":["The Journal of Vascular Access"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11297298211067059","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11297298211067059","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11297298211067059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:19:55Z","timestamp":1777691995000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11297298211067059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1177\/11297298211067059"],"URL":"https:\/\/doi.org\/10.1177\/11297298211067059","relation":{},"ISSN":["1129-7298","1724-6032"],"issn-type":[{"value":"1129-7298","type":"print"},{"value":"1724-6032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,30]]}}}