{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:41:01Z","timestamp":1793090461155,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Arteriovenous fistula (AVF) is the preferred vascular access (VA) for hemodialysis, but it is still affected by high non-maturation and early failure rates due to stenosis development. Increasing evidence suggests that the presence of turbulent-like flow may play a key role, therefore, to stabilize the flow in the venous segment, an external support device (VasQ\n                      <jats:sup>TM<\/jats:sup>\n                      ) has been designed. The aim of this study was to provide preliminary evidence of VasQ\n                      <jats:sup>TM<\/jats:sup>\n                      impact on AVF hemodynamics as compared to AVFs created with conventional surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this pilot single-center prospective randomized study six patients were enrolled, three in the VasQ group and three in the control group. Contrast-free magnetic resonance imaging (MRI) scans were acquired at 3\u2009days, 3\u2009months and 1\u2009year after AVF surgery and were used to generate 3D patient-specific models. Computational fluid dynamic (CFD) simulations were performed using pimpleFoam, imposing patient-specific flow waveforms derived from ultrasound (US) examinations at the inlet of the proximal and distal artery, and a traction-free condition at the venous outflow. Morphologic and hemodynamic changes occurring over time were compared between VasQ and control AVFs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Our MRI protocol provided high-quality images suitable for reliable segmentation and reconstruction of patient-specific 3D models of AVFs at all three timepoints in four out of six patients. The VasQ\n                      <jats:sup>TM<\/jats:sup>\n                      device maintained the angle between the artery and the vein almost unchanged over time, with a more stable flow in the AVFs supported by the device. In contrast, one of the AVFs of the control group evolved to an extreme dilatation of the vein and highly disturbed flow, while the other developed a stenosis in the juxta-anastomotic region.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      This study demonstrated the feasibility of characterizing the morphological and hemodynamic changes occurring over time in AVFs created using the VasQ\n                      <jats:sup>TM<\/jats:sup>\n                      device and provided preliminary evidence of the potential hemodynamic benefits of its use.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11297298221087160","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T07:40:31Z","timestamp":1650613231000},"page":"60-70","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Arteriovenous fistula creation with VasQ\n                    <sup>TM<\/sup>\n                    device: A feasibility study to reveal hemodynamic implications"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-5550","authenticated-orcid":false,"given":"Michela","family":"Bozzetto","sequence":"first","affiliation":[{"name":"Department of Engineering and Applied Sciences, University of Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Soliveri","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering - Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-9925","authenticated-orcid":false,"given":"Sofia","family":"Poloni","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering - Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology, Papa Giovanni XXIII Hospital, University of Milano-Bicocca, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Curt\u00f2","sequence":"additional","affiliation":[{"name":"Unit of Nephrology and Dialysis, ASST Ospedale Papa Giovanni XXIII, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina Carmela","family":"Condemi","sequence":"additional","affiliation":[{"name":"Unit of Nephrology and Dialysis, ASST Ospedale Papa Giovanni XXIII, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Cefal\u00ec","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery, ASST Ospedale Papa Giovanni XXIII, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Spina","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery, ASST Ospedale Papa Giovanni XXIII, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-5701","authenticated-orcid":false,"given":"Alessandro","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Caroli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering - Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-8927","authenticated-orcid":false,"given":"Andrea","family":"Remuzzi","sequence":"additional","affiliation":[{"name":"Department of Management, Information and Production Engineering, University of Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"bibr1-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013111236"},{"key":"bibr2-11297298221087160","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000368"},{"key":"bibr3-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr342"},{"key":"bibr4-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-015-1525-y"},{"key":"bibr5-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-017-0323-0"},{"key":"bibr6-11297298221087160","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000527"},{"key":"bibr7-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.05.023"},{"key":"bibr8-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1177\/1129729820904599"},{"key":"bibr9-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2021.07.120"},{"key":"bibr10-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1177\/1129729820971533"},{"key":"bibr11-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1177\/11297298211002570"},{"key":"bibr12-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1177\/0391398818784207"},{"key":"bibr13-11297298221087160","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-008-0420-1"},{"key":"bibr14-11297298221087160","unstructured":"OpenFoam T. 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