{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:22:56Z","timestamp":1785514976228,"version":"3.56.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Flomatrix Pty Ltd."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Peripheral intravenous catheters (PIVCs) are the most commonly used invasive medical device, yet despite best efforts by end-users, PIVCs experience unacceptably high early failure rates. We aimed to design a new PIVC that reduces the early failure rate of in-dwelling PIVCs and we conducted preliminary tests to assess its efficacy and safety in a porcine model of intravenous access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We used computer-aided design and simulation to create a PIVC with a ramped tip geometry, which directs the infused fluid away from the vein wall; we called the design the FloRamp\u2122. We created FloRamp prototypes (test device) and tested them against a market-leading device (BD Insyte\u2122; control device) in a highly-controlled setting with five insertion sites per device in four pigs. We measured resistance to infusion and visual infusion phlebitis (VIP) every 6\u2009h and terminated the experiment at 48\u2009h. Veins were harvested for histology and seven pathological markers were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Computer simulations showed that the optimum FloRamp tip reduced maximum endothelial shear stress by 60%, from 12.7\u2009Pa to 5.1\u2009Pa, compared to a typical PIVC tip and improved the infusion dynamics of saline in the blood stream. In the animal study, we found that 2\/5 of the control devices were occluded after 24\u2009h, whereas all test devices remained patent and functional. The FloRamp created less resistance to infusion (0.73\u2009\u00b1\u20090.81 vs 0.47\u2009\u00b1\u20090.50, p\u2009=\u20090.06) and lower VIP scores (0.60\u2009\u00b1\u20090.93 vs 0.31\u2009\u00b1\u20090.70, p\u2009=\u20090.09) than the control device, although neither findings were significantly different. Histopathology revealed that 5\/7 of the assessed markers were lower in veins with the FloRamp.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Herein we report preliminary assessment of a novel PIVC design, which could be advantageous in clinical settings through decreased device occlusion and reduced early failure rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11297298221127760","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T01:32:46Z","timestamp":1666661566000},"page":"790-799","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Design, development and preliminary assessment in a porcine model of a novel peripheral intravenous catheter aimed at reducing early failure rates"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-2796","authenticated-orcid":false,"given":"Barry J.","family":"Doyle","sequence":"first","affiliation":[{"name":"Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and the UWA Centre for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia"},{"name":"School of Engineering, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Australian Research Council Centre for Personalised Therapeutics Technologies, Australia"},{"name":"British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachlan J.","family":"Kelsey","sequence":"additional","affiliation":[{"name":"Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and the UWA Centre for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia"},{"name":"School of Engineering, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Shelverton","sequence":"additional","affiliation":[{"name":"Flomatrix Pty Ltd, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Abbate","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ainola","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Sato","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Livingstone","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahe","family":"Bouquet","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R","family":"Passmore","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-5187","authenticated-orcid":false,"given":"Sebastiano","family":"Colombo","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Sato","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keibun","family":"Liu","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silver","family":"Heinsar","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"},{"name":"St Andrews War Memorial Hospital, Spring Hill, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Wildi","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"},{"name":"Cardiovascular Research Institute Basel, University Hospital of Basel and University Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4935-3256","authenticated-orcid":false,"given":"Peter J.","family":"Carr","sequence":"additional","affiliation":[{"name":"Alliance for Vascular Access Teaching and Research (AVATAR) Group, Menzies Health Institute Queensland, School of Nursing and Midwifery, Griffith University, Brisbane, Queensland, Australia"},{"name":"School of Nursing and Midwifery, University of Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Suen","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fraser","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"},{"name":"Queensland University of Technology, Brisbane, Queensland, Australia"},{"name":"Intensive Care Unit, St Andrews War Memorial Hospital, Spring Hill, Queensland, Australia"},{"name":"Intensive Care Unit, The Wesley Hospital, Uniting Care Hospitals, Auchenflower, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Li Bassi","sequence":"additional","affiliation":[{"name":"Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia"},{"name":"Queensland University of Technology, Brisbane, Queensland, Australia"},{"name":"Intensive Care Unit, St Andrews War Memorial Hospital, Spring Hill, Queensland, Australia"},{"name":"Intensive Care Unit, The Wesley Hospital, Uniting Care Hospitals, Auchenflower, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2797-4388","authenticated-orcid":false,"given":"Samantha","family":"Keogh","sequence":"additional","affiliation":[{"name":"Alliance for Vascular Access Teaching and Research (AVATAR) Group, Menzies Health Institute Queensland, School of Nursing and Midwifery, Griffith University, Brisbane, Queensland, Australia"},{"name":"School of Nursing and Centre for Healthcare Transformation, Queensland University of Technology, Brisbane, Queensland, Australia"},{"name":"Nursing and Midwifery Research Centre, Royal Brisbane and Women\u2019s Hospital, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,24]]},"reference":[{"key":"bibr1-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1097\/NAN.0000000000000100"},{"key":"bibr2-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2020.06.205"},{"key":"bibr3-11297298221127760","unstructured":"Burnaby B. Global market overview for vascular acceess devices and accessories 2012\u20132022, 2017. Contract No.: 4339819."},{"key":"bibr4-11297298221127760","unstructured":"Verified Market Research. Global peripheral IV catheter market: market size, status and forecast to 2028, 2020."},{"key":"bibr5-11297298221127760","doi-asserted-by":"publisher","DOI":"10.12788\/jhm.2867"},{"key":"bibr6-11297298221127760","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2009.866"},{"key":"bibr7-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1177\/1129729818820200"},{"key":"bibr8-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.5.677"},{"key":"bibr9-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000229658.76797.30"},{"key":"bibr10-11297298221127760","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00861"},{"key":"bibr11-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21617-1"},{"key":"bibr12-11297298221127760","doi-asserted-by":"publisher","DOI":"10.2309\/JAVA-D-21-00006"},{"key":"bibr13-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14350"},{"key":"bibr14-11297298221127760","unstructured":"National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the care and use of laboratory animals. 8th ed. Washington, DC: National Academies Press (US), 2011, https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK54050\/. (Accessed on 18 February 2020)."},{"issue":"4","key":"bibr15-11297298221127760","volume":"94","author":"Jackson A","year":"1998","journal-title":"Nurs Times"},{"key":"bibr16-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1080\/01926230252824761"},{"key":"bibr17-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00206-4"},{"key":"bibr18-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00234-9"},{"key":"bibr19-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31380-1"},{"key":"bibr20-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01728-1"},{"key":"bibr21-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.22.2.165"},{"key":"bibr22-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1080\/09537100400010352"},{"key":"bibr23-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1186\/cc9322"},{"key":"bibr24-11297298221127760","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.4.1558"}],"container-title":["The Journal of Vascular Access"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11297298221127760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11297298221127760","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11297298221127760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:21:44Z","timestamp":1777692104000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11297298221127760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,24]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1177\/11297298221127760"],"URL":"https:\/\/doi.org\/10.1177\/11297298221127760","relation":{},"ISSN":["1129-7298","1724-6032"],"issn-type":[{"value":"1129-7298","type":"print"},{"value":"1724-6032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,24]]}}}