{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:09:56Z","timestamp":1777936196777,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T00:00:00Z","timestamp":1691280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Calcium gluconate is widely used to treat neonatal hypocalcemia, severe hyperkalemia, and convulsions. However, extravasation of calcium gluconate can lead to iatrogenic calcinosis, causing symptoms such as local redness and swelling, cutaneous plaque, soft tissue calcification, and cutaneous tissue necrosis. Therefore, this study retrospectively analyzed the conservative treatment results of neonatal iatrogenic calcinosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data of neonates diagnosed with iatrogenic calcinosis cutis caused by calcium gluconate exudation between December 2012 and June 2021 were analyzed retrospectively. The clinical data included medical history, physical examination, laboratory findings, and radiographs. All the patients were conservatively treated, and the curative effect and prognosis were followed up by evaluating radiographs and limb function. Patients with complications, such as recurrence or limb dysfunction, were further followed up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, 16 neonates (sex: 10 male and 6 female infants; age: 17.5\u2009\u00b1\u20097.8\u2009days) were included. Iatrogenic calcinosis cutis was located around the left wrist, right wrist, left ankle, and right ankle in four, one, six, and five patients, respectively. Calcification healed within 1\u20133\u2009months (mean: 1.6\u2009\u00b1\u20090.6\u2009months). After a follow-up of 0.5\u20138.5\u2009years (mean: 3.5\u2009\u00b1\u20092.8\u2009years), the appearance, joint function, local growth, and development of the lesion of the neonates with iatrogenic calcinosis cutis were consistent with those of the healthy ones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>For neonatal iatrogenic calcinosis cutis without cutaneous and subcutaneous tissue necrosis, symptomatic support treatment is effective and does not affect the limbs\u2019 appearance and function. Level of evidence: IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11297298231169054","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T02:59:15Z","timestamp":1691377155000},"page":"1860-1867","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal iatrogenic calcinosis cutis caused by calcium gluconate extravasation"],"prefix":"10.1177","volume":"25","author":[{"given":"Changsheng","family":"Pu","sequence":"first","affiliation":[{"name":"Orthopedics Department, Children\u2019s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China"},{"name":"Department of Pediatrics, Women and Children\u2019s Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Women and Children\u2019s Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China"},{"name":"Department of Neonatology, Children\u2019s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menglei","family":"Wang","sequence":"additional","affiliation":[{"name":"Orthopedics Department, Children\u2019s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[{"name":"Lab medicine Department, Chongqing Yubei Maternal and Children Health Hospital, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-5594","authenticated-orcid":false,"given":"Yuxi","family":"Su","sequence":"additional","affiliation":[{"name":"Orthopedics Department, Children\u2019s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Jiangxi Hospital Affiliated Children\u2019s Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,6]]},"reference":[{"key":"bibr1-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2015.09.001"},{"key":"bibr2-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.038"},{"key":"bibr3-11297298231169054","first-page":"277","volume":"19","author":"Caksen H","year":"2002","journal-title":"Pediatr Dermatol"},{"key":"bibr4-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-007-1217-z"},{"key":"bibr5-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001110"},{"key":"bibr6-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.26.6.379"},{"key":"bibr7-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80161-2"},{"key":"bibr8-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2012.04436.x"},{"key":"bibr9-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2019.09.011"},{"key":"bibr10-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-9572(10)60045-9"},{"key":"bibr11-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-1124(77)80280-3"},{"key":"bibr12-11297298231169054","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.121.1.109"},{"key":"bibr13-11297298231169054","volume":"12","author":"Rumancik BE","year":"2020","journal-title":"Cureus"},{"key":"bibr14-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670060068019"},{"key":"bibr15-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6909.2001.tb01520.x"},{"key":"bibr16-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004640"},{"key":"bibr17-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1997.tb00214.x"},{"key":"bibr18-11297298231169054","author":"van Rens MF","journal-title":"J Vasc Access"},{"key":"bibr19-11297298231169054","author":"Bainbridge P","journal-title":"J Vasc Access"},{"key":"bibr20-11297298231169054","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2022.31.8.S4"},{"key":"bibr21-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1097\/00152193-198803000-00020"},{"key":"bibr22-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1097\/NAN.0b013e31821da1b3"},{"key":"bibr23-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1097\/NAN.0b013e31825af323"},{"key":"bibr24-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00776.x"},{"key":"bibr25-11297298231169054","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000120"},{"key":"bibr26-11297298231169054","doi-asserted-by":"publisher","DOI":"10.5070\/D3199019617"},{"key":"bibr27-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14485"},{"key":"bibr28-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-022-03511-y"},{"key":"bibr29-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.028241"},{"key":"bibr30-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.25.4.267"},{"key":"bibr31-11297298231169054","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.25.1.13"}],"container-title":["The Journal of Vascular Access"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11297298231169054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11297298231169054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11297298231169054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:22:41Z","timestamp":1777692161000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11297298231169054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1177\/11297298231169054"],"URL":"https:\/\/doi.org\/10.1177\/11297298231169054","relation":{},"ISSN":["1129-7298","1724-6032"],"issn-type":[{"value":"1129-7298","type":"print"},{"value":"1724-6032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,6]]}}}