{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:56:50Z","timestamp":1785153410064,"version":"3.55.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Dialysis catheter-associated bacteremia in Intensive Care Units (ICUs) increases morbidity and mortality, prolongs hospital admission and increases admission costs. Taurolidine-Citrate-Heparin Locking Solution (TCHLS) is a catheter-locking solution with a broad antimicrobial activity against gram-positive and gram-negative bacteria and fungi. The aim of this study was to analyze the effect of systematic sealing of hemodialysis catheters in the ICUs of the Hospital Cl\u00ednic de Barcelona on the incidence of hemodialysis catheter-related blood stream infections (CRBSI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods:<\/jats:title>\n                    <jats:p>CRBSI episodes of patients who underwent intermittent hemodialysis (IHD) during ICU admission were reviewed. TCHLS was established as a routine dialysis catheter sealing solution in the hospital ICUs in 2015. As a control group an historic pre-TCHLS group from 2010 to 2014 was used. The post-TCHLS period comprised from 2015 to 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 243 and 266 patients required IHD in the pre- and post TCHLS periods, respectively. The number of CRBSI in the pre-TCHLS period was 18 (7.43%) as compared to 9 (3.38%) in the post-TCHLS period (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043). All infections were from percutaneous catheters except for three catheters that were tunneled. There was no association between the location of the catheter and the incidence of CRBSI. The most frequent isolated microorganisms were Gram positive bacteria (48.38%), with a global predominance of\n                      <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                      (32.25%). There were no significant differences in the median days from the start of hemodialysis to the onset of bacteremia (23.5\u2009days in pre-TCHLS group vs 21\u2009days in the post-TCHLS). There were also no significant differences between the days of ICU stay in the CRBSI in both groups or in mortality, being the overall mortality of 65.9%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our population, the systematic application of TCHLS in the sealing of dialysis catheters in critically ill patients reduces the incidence of CRBSI in ICUs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11297298241282370","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:24:12Z","timestamp":1727681052000},"page":"1504-1509","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Reduction of hemodialysis catheter-related blood stream infections in intensive care units after systematic use of taurolidine-citrate-heparin locking solution"],"prefix":"10.1177","volume":"26","author":[{"given":"Jimena","family":"del Risco Zevallos","sequence":"first","affiliation":[{"name":"Nephrology and Renal Transplantation Department, Hospital Cl\u00ednic de Barcelona. University of Barcelona, IDIBAPS, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6461-4170","authenticated-orcid":false,"given":"Al\u00edcia","family":"Molina And\u00fajar","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Department, Hospital Cl\u00ednic de Barcelona. University of Barcelona, IDIBAPS, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gast\u00f3n","family":"Pi\u00f1eiro","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Department, Hospital Cl\u00ednic de Barcelona. University of Barcelona, IDIBAPS, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Morata","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Cl\u00ednic de Barcelona. University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Casals","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Department, Hospital Cl\u00ednic de Barcelona. University of Barcelona, IDIBAPS, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3704-7318","authenticated-orcid":false,"given":"Mario","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Department, Hospital Cl\u00ednic de Barcelona. University of Barcelona, IDIBAPS, Spain"},{"name":"Escuela de Medicina, Universidad de las Am\u00e9ricas, Puebla, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9stor","family":"Fontser\u00e9","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Department, Hospital Cl\u00ednic de Barcelona. University of Barcelona, IDIBAPS, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Maduell","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Department, Hospital Cl\u00ednic de Barcelona. University of Barcelona, IDIBAPS, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Soriano","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Cl\u00ednic de Barcelona. University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Poch","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Department, Hospital Cl\u00ednic de Barcelona. University of Barcelona, IDIBAPS, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2017.09.012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-021-04215-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000792022"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01521-19"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx187"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2021.30.14.S24"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.06.026"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2021.10.022"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.00951.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1129729820942040"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkac181"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3010007"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2363"},{"issue":"11","key":"e_1_3_2_15_2","article-title":"Prophylactic antibiotics for preventing gram-positive infections associated with long-term central venous catheters in adults and children receiving treatment for cancer","volume":"2021","author":"van den Bosch CH","year":"2021","unstructured":"van den Bosch CH, van Woensel J, van de Wetering MD. Prophylactic antibiotics for preventing gram-positive infections associated with long-term central venous catheters in adults and children receiving treatment for cancer. 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